PMID- 9286342
OWN - NLM
STAT- MEDLINE
DCOM- 19971114
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 417
DP  - 1997
TI  - Regulation of CD44 isoform expression and CD44-mediated signaling in human 
      dendritic cells.
PG  - 83-90
AB  - Dendritic cells (DCs) express CD44, a cell surface receptor for the extracellular 
      matrix ligand hyaluronate, involved in cell-cell interactions and cell migration. 
      Besides the "standard" form of CD44, a variety of splice variants contain an 
      additional extracellular region encoded by 10 "variable" exons termed v1 to v10. 
      The standard form of CD44 as well as variants containing exon v6 (CD44v6) are 
      known to play important roles in the immune system, yet largely unexplored in the 
      DC lineage. In this study, we examined the regulation of CD44 isoforms in human 
      DCs derived from monocytes cultivated in the presence of GM-CSF and IL-4. We 
      found that v3, v6 and v9 variants are all up-regulated upon TNF-alpha stimulation 
      of DCs. In addition, we show that stimulation of DCs using anti-CD44 mAbs can 
      induce DC agregation, up-regulation of accessory molecule expression and 
      secretion of cytokines. A mAb directed against CD44v6 variants was shown to 
      mediate some of these effects.
FAU - Haegel-Kronenberger, H
AU  - Haegel-Kronenberger H
AD  - INSERM CJF 94-03, Strasbourg, France.
FAU - de la Salle, H
AU  - de la Salle H
FAU - Bohbot, A
AU  - Bohbot A
FAU - Galon, J
AU  - Galon J
FAU - Tartour, E
AU  - Tartour E
FAU - Cazenave, J P
AU  - Cazenave JP
FAU - Hanau, D
AU  - Hanau D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antibodies, Monoclonal/pharmacology
MH  - Cell Aggregation
MH  - Cell Differentiation/drug effects
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/cytology/drug effects/*immunology
MH  - Genetic Variation
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Humans
MH  - Hyaluronan Receptors/*genetics/*metabolism
MH  - In Vitro Techniques
MH  - Phenotype
MH  - RNA, Messenger/genetics
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - Up-Regulation/drug effects
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1007/978-1-4757-9966-8_14 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 1997;417:83-90. doi: 10.1007/978-1-4757-9966-8_14.