PMID- 9287968
OWN - NLM
STAT- MEDLINE
DCOM- 19970930
LR  - 20190707
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 113
IP  - 3
DP  - 1997 Sep
TI  - The multiple endocrine neoplasia type I gene locus is involved in the 
      pathogenesis of type II gastric carcinoids.
PG  - 773-81
AB  - BACKGROUND & AIMS: Both gastrin and genetic factors were suggested to underlie 
      the pathogenesis of multiple gastric enterochromaffin-like (ECL) cell carcinoids. 
      To assess the role of genetic alterations in carcinoid tumorigenesis, loss of 
      heterozygosity (LOH) at the locus of the multiple endocrine neoplasia type 1 
      (MEN-1) gene was studied in gastric carcinoids of patients with MEN-1 and chronic 
      atrophic type A gastritis (A-CAG), as well as in sporadically arising intestinal 
      carcinoids. METHODS: DNA extracted from archival tissue sections of 35 carcinoid 
      tumors was assessed for LOH with eight polymorphic markers on chromosome 11q13. A 
      combined tumor and family study was performed in 1 patient with 
      MEN-1-Zollinger-Ellison syndrome (ZES). RESULTS: LOH at 11q13 loci was detected 
      in 15 of 20 (75%) MEN-1-ZES carcinoids, and each ECL-cell carcinoid with LOH 
      showed deletion of the wild-type allele. Only 1 of 6 A-CAG carcinoids displayed 
      LOH at the MEN-1 gene locus, and none of the 9 intestinal and rectal carcinoids 
      showed 11q13 LOH. CONCLUSIONS: Gastric ECL-cell carcinoid is an independent tumor 
      type of MEN-1 that shares a common developmental mechanism (via inactivation of 
      the MEN-1 gene) with enteropancreatic and parathyroid MEN-1 tumors. Further 
      analysis of sporadic and A-CAG carcinoids is needed to elucidate genetic factors 
      involved in their tumorigenesis.
FAU - Debelenko, L V
AU  - Debelenko LV
AD  - Laboratory of Pathology, National Cancer Institute, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Zhuang, Z
AU  - Zhuang Z
FAU - Epshteyn, E
AU  - Epshteyn E
FAU - Moskaluk, C A
AU  - Moskaluk CA
FAU - Jensen, R T
AU  - Jensen RT
FAU - Liotta, L A
AU  - Liotta LA
FAU - Lubensky, I A
AU  - Lubensky IA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoid Tumor/*genetics/pathology
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Gastritis/genetics
MH  - Gene Deletion
MH  - Genetic Markers
MH  - Humans
MH  - Intestinal Neoplasms/genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Stomach Neoplasms/*genetics/pathology
MH  - Zollinger-Ellison Syndrome/genetics/pathology
EDAT- 1997/09/01 00:00
MHDA- 1997/09/01 00:01
CRDT- 1997/09/01 00:00
PHST- 1997/09/01 00:00 [pubmed]
PHST- 1997/09/01 00:01 [medline]
PHST- 1997/09/01 00:00 [entrez]
AID - S0016508597004149 [pii]
AID - 10.1016/s0016-5085(97)70171-9 [doi]
PST - ppublish
SO  - Gastroenterology. 1997 Sep;113(3):773-81. doi: 10.1016/s0016-5085(97)70171-9.