PMID- 9290697
OWN - NLM
STAT- MEDLINE
DCOM- 19970930
LR  - 20191024
IS  - 0899-1987 (Print)
IS  - 0899-1987 (Linking)
VI  - 19
IP  - 4
DP  - 1997 Aug
TI  - Frequent inactivation of the p16 gene in human pituitary tumors by gene 
      methylation.
PG  - 221-4
AB  - Rodent models of pituitary tumorigenesis have implicated the retinoblastoma (Rb) 
      pathway in the development of pituitary tumors. Previously, we reported that loss 
      of p16 expression rather than loss of Rb occurs in most human pituitary adenomas. 
      This alteration in these tumors is not associated with p16 mutation or frequent 
      homozygous p16 gene loss. Our laboratory has now demonstrated that in most human 
      pituitary tumors, the 5' CpG island of the p16 gene is extensively methylated. 
      The high frequency of p16 gene methylation in human pituitary tumors suggests 
      that this alteration is an early and perhaps required event in pituitary cell 
      transformation.
FAU - Woloschak, M
AU  - Woloschak M
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, 
      USA.
FAU - Yu, A
AU  - Yu A
FAU - Post, K D
AU  - Post KD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - 0 (Carrier Proteins)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adenoma/*genetics/*metabolism
MH  - Carrier Proteins/biosynthesis/*genetics
MH  - Cyclin-Dependent Kinase Inhibitor p16
MH  - *DNA Methylation
MH  - DNA, Neoplasm/genetics/*metabolism
MH  - Exons
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Pituitary Neoplasms/*genetics/*metabolism
MH  - Polymerase Chain Reaction
EDAT- 1997/08/01 00:00
MHDA- 1997/09/18 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/09/18 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2744(199708)19:4<221::AID-MC1>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1098-2744(199708)19:4<221::aid-mc1>3.0.co;2-f [doi]
PST - ppublish
SO  - Mol Carcinog. 1997 Aug;19(4):221-4. doi: 
      10.1002/(sici)1098-2744(199708)19:4<221::aid-mc1>3.0.co;2-f.