PMID- 9291264
OWN - NLM
STAT- MEDLINE
DCOM- 19971008
LR  - 20231213
IS  - 0266-4356 (Print)
IS  - 0266-4356 (Linking)
VI  - 35
IP  - 4
DP  - 1997 Aug
TI  - Expression of retinoic acid receptors in normal, dysplastic and malignant oral 
      epithelia.
PG  - 260-6
AB  - Chemoprevention with retinoic acid (RA) derivatives may reduce the incidence of 
      transformation of potentially malignant oral lesions, and help prevent 
      development of second primary tumours in the upper aerodigestive tract. At 
      present, little is known about the mechanisms by which RA derivatives modify cell 
      proliferation and differentiation. RA interacts with two classes of nuclear 
      receptors: the retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We 
      have used immunohistology to localise these receptors on normal epidermis and 
      oral mucosa. The distribution of RAR and RXR suggests that RA may exert complex 
      growth regulatory effects on oral mucosa. Increased levels of RAR and RXR, 
      together with alterations in the patterns of expression of these receptors, were 
      seen when dysplastic and malignant epithelia were compared to normal oral mucosa. 
      These findings suggest that expression of RAR and RXR receptors is modulated in 
      epithelia showing altered growth regulation.
FAU - Sherman, J A
AU  - Sherman JA
AD  - The Royal Surrey County Hospital, Guildford, UK.
FAU - Partridge, M
AU  - Partridge M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
RN  - 0 (Nuclear Proteins)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Carcinoma, Squamous Cell/*chemistry
MH  - Cell Division/drug effects
MH  - Cell Nucleus/chemistry
MH  - Cytoplasm/chemistry
MH  - Epidermis/chemistry
MH  - Epithelium/chemistry
MH  - Gene Expression
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Leukoplakia, Oral/*chemistry
MH  - Mouth Mucosa/*chemistry
MH  - Mouth Neoplasms/*chemistry
MH  - Nuclear Proteins/analysis
MH  - Receptors, Retinoic Acid/*analysis
MH  - Retinoic Acid Receptor alpha
MH  - Retinoid X Receptors
MH  - Retinoids/pharmacology
MH  - Transcription Factors/analysis
MH  - Retinoic Acid Receptor gamma
EDAT- 1997/08/01 00:00
MHDA- 1997/09/18 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/09/18 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1016/s0266-4356(97)90044-9 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 1997 Aug;35(4):260-6. doi: 
      10.1016/s0266-4356(97)90044-9.