PMID- 9292182
OWN - NLM
STAT- MEDLINE
DCOM- 19971023
LR  - 20191102
IS  - 1050-6586 (Print)
IS  - 1050-6586 (Linking)
VI  - 11
IP  - 4
DP  - 1997 Jul-Aug
TI  - Capsaicin's effect on rat nasal mucosa substance P release: experimental basis 
      for vasomotor rhinitis treatment.
PG  - 313-6
AB  - Substance P (SP) is one of several neuropeptides found in nasal mucosa. It exists 
      primarily in sensory afferent neurons, which are best demonstrated by 
      immunohistochemical staining. These substance P-like immunoreactive (SPLI) nerve 
      fibers are unmyelinated C fibers, which connect to the trigeminal ganglion and 
      the spinal trigeminal nucleus. They are found around vessels and seromucinous 
      glands in the submucosa. When the nasal mucosa receives a noxious stimulus, SP is 
      released and acts orthodromically as a comediator of nasal pain, while 
      antidromically it induces vasodilatation, plasma extravasation, mucosal edema, 
      and rhinorrhea. Its antidromic effects have been implicated in vasomotor rhinitis 
      and can be blocked by topical intranasal capsaicin application. Wolf and others 
      have demonstrated in human subjects that vasomotor rhinitis can be blocked up to 
      1 year by a series of intranasal capsaicin applications. It has not yet been 
      demonstrated that nasal mucous SP levels following noxious nasal stimulus change 
      after intranasal capsaicin pretreatment. Consequently a project was designed to 
      determine whether intranasal capsaicin pretreatment would affect nasal substance 
      P release measured in nasal secretion. Nasal secretion SP levels were measured 
      before and after noxious nasal stimulus in controls and in capsaicin pretreated 
      rats. The difference in measured nasal secretion SP levels were significant (p < 
      0.05).
FAU - Kuhn, F A
AU  - Kuhn FA
AD  - Georgia Rhinology and Sinus Center, Georgia Ear Institute, Savannah 31403-3665, 
      USA.
FAU - Gonzalez, S
AU  - Gonzalez S
FAU - Rodriguez, M
AU  - Rodriguez M
FAU - Siller, C C
AU  - Siller CC
FAU - Zachariou, V
AU  - Zachariou V
FAU - Goldstein, B D
AU  - Goldstein BD
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol
JT  - American journal of rhinology
JID - 8807268
RN  - 33507-63-0 (Substance P)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Capsaicin/administration & dosage/*pharmacology
MH  - Exudates and Transudates/metabolism
MH  - Male
MH  - Nasal Mucosa/*drug effects/metabolism
MH  - Nasal Provocation Tests
MH  - Rats
MH  - Rats, Inbred WF
MH  - Rhinitis/*drug therapy
MH  - Substance P/analysis/drug effects/*metabolism
EDAT- 1997/07/01 00:00
MHDA- 1997/09/18 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/09/18 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.2500/105065897781446649 [doi]
PST - ppublish
SO  - Am J Rhinol. 1997 Jul-Aug;11(4):313-6. doi: 10.2500/105065897781446649.