PMID- 9292549
OWN - NLM
STAT- MEDLINE
DCOM- 19970930
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 90
IP  - 5
DP  - 1997 Sep 1
TI  - Association of specific cytomegalovirus genotypes with death from 
      myelosuppression after marrow transplantation.
PG  - 2097-102
AB  - A retrospective analysis of cytomegalovirus (CMV) genotype was conducted on 281 
      CMV isolates obtained from marrow transplant recipients. The genotyping was based 
      on sequence variations in the gene encoding envelope glycoprotein B (gB) as 
      detected by restriction analysis of polymerase chain reaction (PCR)-amplified gB 
      DNA. Among all isolates studied, the distribution of gB types 1-4 was 48.4%, 
      16.4%, 24.6%, and 8.2%, respectively, with only 2.5% of all isolates containing 
      more than one gB type. The association of gB types with acute 
      graft-versus-host-disease (GVHD) and death related to myelosuppression was 
      examined using appropriate multivariable regression models. Covariables in 
      addition to gB type included underlying disease type, donor-recipient HLA 
      matching, donor CMV serostatus, and age as a continuous variable. Death 
      associated with myelosuppression occurred in 2.9% or 4 of 136 patients with gB1, 
      0% or 0 of 46 patients with gB2, 21.7% or 15 of 69 patients with gB3, and 17.4% 
      or four of 23 patients with gB4. The significant association of CMV gB type with 
      death due to myelosuppression was maintained in a multivariable analysis (P < 
      .001). In addition, the data also suggested that gB types 3 and 4 may be 
      associated with a reduced hazard of grades II to IV acute GVHD.
FAU - Torok-Storb, B
AU  - Torok-Storb B
AD  - Fred Hutchinson Cancer Research Center and University of Washington School of 
      Medicine, Seattle 98104-2092, USA.
FAU - Boeckh, M
AU  - Boeckh M
FAU - Hoy, C
AU  - Hoy C
FAU - Leisenring, W
AU  - Leisenring W
FAU - Myerson, D
AU  - Myerson D
FAU - Gooley, T
AU  - Gooley T
LA  - eng
GR  - CA18029/CA/NCI NIH HHS/United States
GR  - CA18221/CA/NCI NIH HHS/United States
GR  - HL36444/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein B, Simplexvirus)
SB  - IM
MH  - Adult
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Cytomegalovirus/*genetics
MH  - Cytomegalovirus Infections/blood/etiology/mortality/*virology
MH  - Graft vs Host Disease/etiology/virology
MH  - Hematologic Neoplasms/*therapy
MH  - Humans
MH  - Leukocytes/*pathology
MH  - Transplantation, Homologous
MH  - Viral Envelope Proteins/*genetics
EDAT- 1997/09/18 00:00
MHDA- 1997/09/18 00:01
CRDT- 1997/09/18 00:00
PHST- 1997/09/18 00:00 [pubmed]
PHST- 1997/09/18 00:01 [medline]
PHST- 1997/09/18 00:00 [entrez]
AID - S0006-4971(20)58823-X [pii]
PST - ppublish
SO  - Blood. 1997 Sep 1;90(5):2097-102.