PMID- 9292591
OWN - NLM
STAT- MEDLINE
DCOM- 19970925
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 15
IP  - 4
DP  - 1997 Aug 1
TI  - HIV viral load and CD4+ lymphocyte counts in subjects coinfected with HTLV-I and 
      HIV-1.
PG  - 308-11
AB  - Reports indicate that there is a dissociation between markers of HIV disease 
      progression and clinical stage among subjects coinfected with human T-cell 
      lymphotropic virus type I (HTLV-I) and HIV. HTLV-I coinfection does not appear to 
      affect HIV viral load, currently considered to be the best marker of HIV disease 
      progression. We measured HIV RNA levels in stored serum samples from 23 subjects 
      with coinfection and 92 subjects with HIV single infection and examined the 
      correlation with the CD4+ lymphocyte count. Subjects were recruited from an 
      ongoing HIV cohort study in Rio de Janeiro, Brazil. In both groups, CD4+ 
      lymphocyte counts declined with increasing levels of HIV RNA. In a linear 
      regression analysis adjusting for HIV RNA serum level, coinfected individuals had 
      an estimated 78% higher CD4+ lymphocyte count than those with single infection. 
      Simultaneous adjustment for beta2-microglobulin level increased the difference, 
      with coinfected individuals having 146% (p = 0.005, 95% CI: 32% to 359%) higher 
      CD4+ counts. These data suggest that the higher CD4+ lymphocyte counts associated 
      with coinfection do not provide immunologic benefit and may reflect 
      HTLV-I-associated nonspecific lymphocyte proliferation. The results of this and 
      other studies suggest that the CD4+ count cutoff values used in making clinical 
      decisions in HIV infection may not be appropriate in coinfection. As with HIV 
      single infection, HIV virus load may be the optimal surrogate marker for subjects 
      with coinfection.
FAU - Schechter, M
AU  - Schechter M
AD  - Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, 
      Universidade Federal do Rio de Janeiro, Brazil. maurosch@ax.apc.org
FAU - Moulton, L H
AU  - Moulton LH
FAU - Harrison, L H
AU  - Harrison LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/immunology/*virology
MH  - CD4 Lymphocyte Count
MH  - HIV/genetics/*isolation & purification
MH  - *HIV-1
MH  - HTLV-I Infections/immunology/*virology
MH  - Humans
MH  - RNA, Viral/analysis
EDAT- 1997/08/01 00:00
MHDA- 1997/09/18 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/09/18 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1097/00042560-199708010-00010 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 1;15(4):308-11. doi: 
      10.1097/00042560-199708010-00010.