PMID- 9295145
OWN - NLM
STAT- MEDLINE
DCOM- 19971023
LR  - 20190905
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 386
IP  - 2
DP  - 1997 Sep 22
TI  - Atlas of the neurons that express mRNA for the long form of the prolactin 
      receptor in the forebrain of the female rat.
PG  - 161-77
AB  - Prolactin has a variety of important physiological effects on peripheral tissue 
      and on the brain. The behavioral effects of prolactin include the induction of 
      maternal behavior and increased food intake. Prolactin acts via its cognate 
      receptors which have two forms, a short and a long form. The long form of the 
      receptor is predominant in the preoptic area-hypothalamus and is positioned to 
      support maternal behavior since this form is regulated across pregnancy and 
      lactation (Nagano and Kelly [1994] J. Biol. Chem. 269:13337-13345; Sugiyama et 
      al. [1994] J. Endocrinol. 141:325-333). By using in situ hybridization with [33P] 
      labelled cRNA probe specific for the long form of the receptor mRNA(L-PRL mRNA) 
      we have mapped, in brains from 2- and 21-day-old pregnant females, the 
      neuroanatomical distribution of neurons expressing the long form of the receptor. 
      Many neurons with high expression of L-PRL mRNA were located in the anteroventral 
      periventricular nucleus, the medial preoptic area (MPO), specific subdivisions of 
      the paraventricular and supraoptic nuclei, and in the arcuate and ventromedial 
      nuclei. Labelled neurons were also found in limbic system structures such as the 
      bed nucleus of stria terminalis (BST) and the medial nucleus of the amygdala, in 
      a few thalamic nuclei, and in the central gray. All cells throughout the choroid 
      plexus expressed high levels of L-PRL mRNA. The levels of L-PRL mRNA were higher 
      in females on day 21 of pregnancy in the MPO and in the choroid plexus, than in 
      females on day 2 of pregnancy; levels in the ventromedial nucleus of the 
      hypothalamus (VMH) were unchanged across pregnancy. The neuroanatomical 
      distribution of neurons expressing L-PRL mRNA may have special relevance for the 
      mediation of maternal behavior, lactation, sexual behavior, and feeding.
FAU - Bakowska, J C
AU  - Bakowska JC
AD  - Institute of Animal Behavior, Rutgers University, Newark, New Jersey 07102, USA. 
      aszi@pegasus.rutgers.edu
FAU - Morrell, J I
AU  - Morrell JI
LA  - eng
GR  - HD 22983/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (DNA Probes)
RN  - 0 (Phosphorus Radioisotopes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Prolactin)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Choroid Plexus/metabolism
MH  - DNA Probes
MH  - Female
MH  - In Situ Hybridization
MH  - Male
MH  - Neurons/*metabolism
MH  - Phosphorus Radioisotopes
MH  - Pregnancy
MH  - Prosencephalon/*anatomy & histology/cytology/*metabolism
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Prolactin/*biosynthesis
EDAT- 1997/09/19 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/09/19 00:00
PHST- 1997/09/19 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/09/19 00:00 [entrez]
AID - 10.1002/(SICI)1096-9861(19970922)386:2<161::AID-CNE1>3.0.CO;2-# [pii]
AID - 10.1002/(sici)1096-9861(19970922)386:2<161::aid-cne1>3.0.co;2-# [doi]
PST - ppublish
SO  - J Comp Neurol. 1997 Sep 22;386(2):161-77. doi: 
      10.1002/(sici)1096-9861(19970922)386:2<161::aid-cne1>3.0.co;2-#.