PMID- 9297507
OWN - NLM
STAT- MEDLINE
DCOM- 19980211
LR  - 20190831
IS  - 0009-5915 (Print)
IS  - 0009-5915 (Linking)
VI  - 106
IP  - 5
DP  - 1997 Oct
TI  - Sequential immunocytogenetics, molecular cytogenetics and transmission electron 
      microscopy of microspread meiosis I oocytes from a human fetal carrier of an 
      unbalanced translocation.
PG  - 293-303
AB  - The oocytes of a 17 week human fetus carrying an unbalanced 46,XX, add(18)(p13) 
      translocation were studied with a sequential combination of microspreading, 
      immunocytogenetics, fluorescence in situ hybridization (FISH) and transmission 
      electron microscopy. This combination of technologies allowed the collection of 
      data of unique accuracy and resolution. The translocated chromosome was found to 
      be involved in five different synaptic configurations. A consistent feature of 
      these configurations was the involvement of a second small bivalent, presumably 
      chromosome 21 or 22, the normal synapsis of which was often disrupted. We 
      conclude that chromosome 21 or 22 was the source of the translocated material, 
      which was found to be either homologously triply synapsed, heterologously 
      synapsed or asynapsed.
FAU - Barlow, A L
AU  - Barlow AL
AD  - LSF Research Unit, Regional Genetics Services, Heartlands Hospital, Yardley Green 
      Road, Birmingham B9 5PX, UK.
FAU - Hulten, M A
AU  - Hulten MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Chromosoma
JT  - Chromosoma
JID - 2985138R
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 18
MH  - Cytogenetics/*methods
MH  - Embryo, Mammalian/physiology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - *Meiosis
MH  - Microscopy, Electron
MH  - Oocytes/*physiology
MH  - Pregnancy
MH  - *Translocation, Genetic
EDAT- 1997/09/23 00:00
MHDA- 1997/09/23 00:01
CRDT- 1997/09/23 00:00
PHST- 1997/09/23 00:00 [pubmed]
PHST- 1997/09/23 00:01 [medline]
PHST- 1997/09/23 00:00 [entrez]
AID - 10.1007/s004120050250 [doi]
PST - ppublish
SO  - Chromosoma. 1997 Oct;106(5):293-303. doi: 10.1007/s004120050250.