PMID- 9299608
OWN - NLM
STAT- MEDLINE
DCOM- 19971015
LR  - 20161124
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 146
IP  - 1
DP  - 1997 Sep
TI  - Effects of maternal exposure to 3,3',4,4'-tetrachlorobiphenyl or propylthiouracil 
      in rats trained to discriminate apomorphine from saline.
PG  - 162-9
AB  - In the present experiment drug discrimination was examined in rats after maternal 
      exposure to 3,3',4,4'-tetrachlorobiphenyl (PCB 77) using apomorphine (APO) as the 
      training drug at a dose reported to act on dopamine D2 receptors. A group with 
      maternal exposure to 6n-propyl-2-thiouracil (PTU) was included as a positive 
      control for effects induced by PCB 77 on thyroid hormones. On gestational day 
      (GD) 19 reduced levels of free and total thyroxine (FT4, TT4) and free 
      triiodothyronine (FT3) were detected in dams exposed to PCB 77 or PTU. In the 
      offspring decreases in levels of FT4 and TT4 were found in both treated groups on 
      postnatal day (PND) 21, while reductions of FT3 were observed only in the PTU 
      group. PTU-treated rats needed more daily sessions for successful discrimination 
      between apomorphine and saline. There were no differences between groups in 
      generalization tests and sessions with the D2/D3 agonist quinpirole, the D2 
      antagonist haloperidol plus APO, or with the GABAergic drug pentobarbital and 
      only minor differences in sessions with the D1 agonist SKF-38393. Differences 
      between controls and groups exposed to PCB 77 or PTU were detected in a blocking 
      test using the mixed serotonin 5-HT1A agonist and partial D2 antagonist 
      buspirone. This outcome suggests long-lasting effects by developmental exposure 
      to PCB 77 on the interaction between dopaminergic and serotonergic processes 
      which may be mediated by effects on thyroid hormone levels.
CI  - Copyright 1997 Academic Press.
FAU - Lilienthal, H
AU  - Lilienthal H
AD  - Department of Biological Psychology, Heinrich-Heine-University, Auf'm Hennekamp 
      50, Dusseldorf, D-40225, Germany.
FAU - Weinand-Harer, A
AU  - Weinand-Harer A
FAU - Winterhoff, H
AU  - Winterhoff H
FAU - Winneke, G
AU  - Winneke G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Thyroid Hormones)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 721M9407IY (Propylthiouracil)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - N21FAR7B4S (Apomorphine)
RN  - Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Apomorphine/*pharmacology
MH  - Discrimination Learning/*drug effects
MH  - Female
MH  - Fetus/*drug effects
MH  - Hydroxyindoleacetic Acid/analysis
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - Propylthiouracil/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/analysis
MH  - Thyroid Hormones/blood
EDAT- 1997/09/23 00:00
MHDA- 1997/09/23 00:01
CRDT- 1997/09/23 00:00
PHST- 1997/09/23 00:00 [pubmed]
PHST- 1997/09/23 00:01 [medline]
PHST- 1997/09/23 00:00 [entrez]
AID - S0041-008X(97)98245-4 [pii]
AID - 10.1006/taap.1997.8245 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1997 Sep;146(1):162-9. doi: 10.1006/taap.1997.8245.