PMID- 9300545
OWN - NLM
STAT- MEDLINE
DCOM- 19971217
LR  - 20191210
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 62
IP  - 3
DP  - 1997 May-Jun
TI  - Effect of heparin on a haemagglutinin of porcine reproductive and respiratory 
      syndrome virus.
PG  - 261-4
AB  - Heparin inhibited haemagglutination by porcine reproductive and respiratory 
      syndrome virus (PRRSV) and by Aujesky's disease virus, but failed to inhibit 
      haemagglutination by parainfluenza virus type 3. The minimal inhibitory 
      concentration of heparin required to inhibit 8 HA U of PRRSV haemagglutinin 
      ranged from 0.1 to 1 U ml-1. Mouse erythrocytes failed to combine with the 
      haemagglutination inhibitory factor of heparin. However, mouse erythrocytes 
      treated with heparinase had greatly reduced agglutinability by PRRSV. The 
      formation of a haemagglutinin-heparin complex could be observed by sedimenting 
      heparin with the haemagglutinin. All these findings suggest that a heparin-like 
      molecule on the surface of mouse erythrocytes serves as the virus-cell receptor.
FAU - Jusa, E R
AU  - Jusa ER
AD  - Department of Veterinary Epizootiology, College of Bioresource Sciences, Nihon 
      University, Kanagawa, Japan.
FAU - Inaba, Y
AU  - Inaba Y
FAU - Kono, M
AU  - Kono M
FAU - Asagoe, T
AU  - Asagoe T
FAU - Uwatoko, K
AU  - Uwatoko K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Hemagglutinins, Viral)
RN  - 9005-49-6 (Heparin)
RN  - EC 4.2.2.7 (Heparin Lyase)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - Dose-Response Relationship, Drug
MH  - Erythrocytes/cytology/drug effects/metabolism
MH  - Hemagglutination, Viral/*drug effects
MH  - Hemagglutinins, Viral/*drug effects/physiology
MH  - Heparin/metabolism/*pharmacology
MH  - Heparin Lyase/pharmacology
MH  - Herpesvirus 1, Suid/drug effects/physiology
MH  - Kidney/cytology/drug effects/metabolism
MH  - Mice
MH  - Porcine respiratory and reproductive syndrome virus/*drug effects/physiology
MH  - Respirovirus/drug effects/physiology
MH  - Swine
EDAT- 1997/05/01 00:00
MHDA- 1997/09/23 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/09/23 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1016/s0034-5288(97)90201-0 [doi]
PST - ppublish
SO  - Res Vet Sci. 1997 May-Jun;62(3):261-4. doi: 10.1016/s0034-5288(97)90201-0.