PMID- 9300612
OWN - NLM
STAT- MEDLINE
DCOM- 19971201
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 58
IP  - 2
DP  - 1997 Oct
TI  - Time course analysis of the discriminative stimulus effects of the optical 
      isomers of 3,4-methylenedioxymethamphetamine (MDMA).
PG  - 505-16
AB  - The present study examined the discriminative stimulus effects of the MDMA 
      optical isomers administered at different presession injection intervals. In the 
      first experiment, male Sprague-Dawley rats were trained in a two-lever, 
      food-reinforced operant procedure to discriminate either (+)-MDMA (1.25 mg/kg) or 
      (-)-MDMA (3.50 mg kg) at either 20 or 90 min following injection. Animals 
      administered (+)-MDMA or saline 90 min before training sessions failed to attain 
      the discrimination criteria after 73 training sessions, whereas (-)-MDMA 
      successfully established discriminative stimulus control at both the 20 min and 
      the 90 min postinjection intervals. (+)-Amphetamine did not substitute for either 
      isomer, although a significant amount of drug-appropriate responding occurred in 
      animals trained to discriminate (+)-MDMA at 20 min and (-)-MDMA at 90 min. Sch 
      39166 partially reduced the discrimination of (+)-MDMA at 20 min and (-)-MDMA at 
      90 min, although this effect was not dose dependent. Sch 39166 had no effect on 
      animals trained to discriminate (-)-MDMA at 20 min. Haloperidol did not alter the 
      discrimination of (+)-MDMA at 20 min but partially reduced the discriminative 
      stimulus control of (-)-MDMA at 20 min and (-)-MDMA at 90 min. Fenfluramine 
      substituted for both isomers of MDMA. Pirenpirone completely blocked the 
      discriminative stimulus effects of (-)-MDMA at 20 min, although (+)-MDMA at 20 
      min and (-)-MDMA at 90 min were only partly blocked. WAY 100,135 had little 
      effect on drug-appropriate responding; however, the discrimination of (+)-MDMA at 
      20 min was partly reduced by this 5-HT1A antagonist. In a second experiment, rats 
      trained to discriminate (+)-MDMA (1.5 mg/kg) or (-)-MDMA (3.0 mg/kg) from saline 
      were administered substitution tests with both isomers 20, 60, 90 and 120 min 
      after injection. Results confirmed those of the first experiment that (+)-MDMA 
      appears to have a shorter duration of action than (-)-MDMA. These results are 
      discussed in light of the training doses employed.
FAU - Baker, L E
AU  - Baker LE
AD  - Department of Psychology, Western Michigan University, Kalamazoo 49008, USA.
FAU - Virden, T B
AU  - Virden TB
FAU - Miller, M E
AU  - Miller ME
FAU - Sullivan, C L
AU  - Sullivan CL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Hallucinogens)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Discrimination, Psychological/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereoisomerism
MH  - Time Factors
EDAT- 1997/09/23 00:00
MHDA- 1997/09/23 00:01
CRDT- 1997/09/23 00:00
PHST- 1997/09/23 00:00 [pubmed]
PHST- 1997/09/23 00:01 [medline]
PHST- 1997/09/23 00:00 [entrez]
AID - S0091-3057(97)00287-6 [pii]
AID - 10.1016/s0091-3057(97)00287-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1997 Oct;58(2):505-16. doi: 
      10.1016/s0091-3057(97)00287-6.