PMID- 9300703
OWN - NLM
STAT- MEDLINE
DCOM- 19971008
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 159
IP  - 6
DP  - 1997 Sep 15
TI  - Early neutralizing antibody response against mouse mammary tumor virus: critical 
      role of viral infection and superantigen-reactive T cells.
PG  - 2807-14
AB  - Infectious mouse mammary tumor virus (MMTV) is a retrovirus that expresses a 
      superantigen shortly after infection of B cells. The superantigen first drives 
      the polyclonal activation and proliferation of superantigen-reactive CD4+ T 
      cells, which then induce the infected B cells to proliferate and differentiate. 
      Part of the MMTV-induced B cell response leads to the production of Abs that are 
      specific for the viral envelope protein gp52. Here we show that this Ab response 
      has virus-neutralizing activity and confers protection against superinfection by 
      other MMTV strains in vivo as soon as 4 to 7 days after infection. A protective 
      Ab titer is maintained lifelong. Viral infection as well as the 
      superantigen-induced T-B collaboration are required to generate this rapid and 
      long lasting neutralizing Ab response. Polyclonal or superantigen-independent B 
      cell activation, on the contrary, does not lead to detectable virus 
      neutralization. The early onset of this superantigen-dependent neutralizing 
      response suggests that viral envelope-specific B cells are selectively recruited 
      to form part of the extrafollicular B cell response and are subsequently 
      amplified and maintained by superantigen-reactive Th cells.
FAU - Luther, S A
AU  - Luther SA
AD  - Ludwig Institute for Cancer Research, Lausanne Branch, Switzerland.
FAU - Maillard, I
AU  - Maillard I
FAU - Luthi, F
AU  - Luthi F
FAU - Scarpellino, L
AU  - Scarpellino L
FAU - Diggelmann, H
AU  - Diggelmann H
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Viral)
RN  - 0 (Superantigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*immunology
MH  - B-Lymphocytes/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology/virology
MH  - Immunity
MH  - Lymphocyte Activation/immunology
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Retroviridae Infections/*immunology
MH  - Superantigens/*immunology
MH  - Tumor Virus Infections/*immunology
EDAT- 1997/09/23 00:00
MHDA- 1997/09/23 00:01
CRDT- 1997/09/23 00:00
PHST- 1997/09/23 00:00 [pubmed]
PHST- 1997/09/23 00:01 [medline]
PHST- 1997/09/23 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1997 Sep 15;159(6):2807-14.