PMID- 9301995
OWN - NLM
STAT- MEDLINE
DCOM- 19971030
LR  - 20190512
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 40
IP  - 2
DP  - 1997 Aug
TI  - Comparative effects of clindamycin and ampicillin on superantigenic activity of 
      Streptococcus pyogenes.
PG  - 275-7
AB  - We have tested the ability of Streptococcus pyogenes to produce streptococcal 
      pyrogenic exotoxin A (SPEA) and superantigenic activity in the presence of 
      sub-inhibitory concentrations of ampicillin and clindamycin. After 6 h of 
      culture, SPEA production by S. pyogenes was higher in broths containing 
      ampicillin (715.7 +/- 296.4 pg/10(6) cfu) than in broths containing clindamycin 
      (167.1 +/- 31.9 pg/10(6) cfu), a difference that was not significant (P = 0.25). 
      Promitogenic activity of bacterial supernatants was also greater in 
      ampicillin-treated cultures (467.5 +/- 17.2 ccpm/10(6) cfu) than in 
      clindamycin-treated cultures (169.2 +/- 8.9 ccpm/10(6) cfu), a difference that 
      was highly significant (P = 0.0001). The data support the use of clindamycin in 
      the treatment of streptococcal toxic shock-like syndrome, in order to inhibit 
      superantigen synthesis.
FAU - Sriskandan, S
AU  - Sriskandan S
AD  - Department of Infectious Diseases, Royal Postgraduate Medical School, London, UK.
FAU - McKee, A
AU  - McKee A
FAU - Hall, L
AU  - Hall L
FAU - Cohen, J
AU  - Cohen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Exotoxins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Penicillins)
RN  - 0 (Pyrogens)
RN  - 0 (SpeA protein, Streptococcus pyogenes)
RN  - 0 (Superantigens)
RN  - 0 (erythrogenic toxin)
RN  - 3U02EL437C (Clindamycin)
RN  - 7C782967RD (Ampicillin)
SB  - IM
MH  - Ampicillin/*pharmacology
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Antigens, Bacterial/*drug effects/metabolism
MH  - *Bacterial Proteins
MH  - Clindamycin/*pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exotoxins/*metabolism
MH  - *Membrane Proteins
MH  - Penicillins/*pharmacology
MH  - Pyrogens/*metabolism
MH  - Streptococcus pyogenes/*drug effects/immunology/metabolism
MH  - Superantigens/drug effects/metabolism
EDAT- 1997/08/01 00:00
MHDA- 1997/09/25 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/09/25 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1093/jac/40.2.275 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 1997 Aug;40(2):275-7. doi: 10.1093/jac/40.2.275.