PMID- 9302091
OWN - NLM
STAT- MEDLINE
DCOM- 19971113
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 232
IP  - 2
DP  - 1997 Aug 29
TI  - Centrally administered choline increases plasma prolactin levels in conscious 
      rats.
PG  - 79-82
AB  - Intracerebroventricular (i.c.v.) administration of choline, a precursor of 
      acetylcholine (ACh) increased plasma prolactin levels in a time and 
      dose-dependent manner in conscious rats. Pretreatment of rats with the 
      cholinergic muscarinic antagonist, atropine (10 microg, i.c.v.), blocked the 
      increase in plasma prolactin level. The increase was not influenced by 
      pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 microg, 
      i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 microg, i.c.v.), a high 
      affinity choline uptake inhibitor, attenuated the choline-induced increase of 
      plasma prolactin levels. These results show that choline increases plasma 
      prolactin levels by activating muscarinic receptors via presynaptic mechanisms.
FAU - Gurun, M S
AU  - Gurun MS
AD  - Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey.
FAU - Savci, V
AU  - Savci V
FAU - Ulus, I H
AU  - Ulus IH
FAU - Kiran, B K
AU  - Kiran BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Cholinergic Agents)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Nicotinic Antagonists)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 7C0697DR9I (Atropine)
RN  - 9002-62-4 (Prolactin)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Choline/*administration & dosage
MH  - Cholinergic Agents/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hemicholinium 3/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Muscarinic Antagonists/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Prolactin/*blood/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 1997/08/29 00:00
MHDA- 1997/09/25 00:01
CRDT- 1997/08/29 00:00
PHST- 1997/08/29 00:00 [pubmed]
PHST- 1997/09/25 00:01 [medline]
PHST- 1997/08/29 00:00 [entrez]
AID - S0304-3940(97)00580-6 [pii]
AID - 10.1016/s0304-3940(97)00580-6 [doi]
PST - ppublish
SO  - Neurosci Lett. 1997 Aug 29;232(2):79-82. doi: 10.1016/s0304-3940(97)00580-6.