PMID- 9303064
OWN - NLM
STAT- MEDLINE
DCOM- 19971016
LR  - 20131121
IS  - 1065-7541 (Print)
IS  - 1065-7541 (Linking)
VI  - 5
IP  - 3
DP  - 1997
TI  - Molecular identification of individuals at high risk for lung cancer.
PG  - 103-5
AB  - The objective of the work reviewed herein was to evaluate whether a cancerization 
      field-consisting of cells with genetic alterations can be detected within 
      normal-appearing bronchial epithelium. By using fluorescence in situ 
      hybridization (FISH) for trisomy 7, cancerization fields were detected in the 
      majority of cancer patients and also in significant percentages of cancer-free 
      tobacco smokers and former uranium miners. These results suggest that molecular 
      analyses may enhance the power of detecting premalignant changes in bronchial 
      epithelium and may ultimately lead to identifying persons at greatest risk for 
      developing lung cancer.
FAU - Lechner, J F
AU  - Lechner JF
AD  - Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA. 
      jlechner@lrri.org
FAU - Neft, R E
AU  - Neft RE
FAU - Gilliland, F D
AU  - Gilliland FD
FAU - Crowell, R E
AU  - Crowell RE
FAU - Belinsky, S A
AU  - Belinsky SA
LA  - eng
GR  - 1-P50-CA58184/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Radiat Oncol Investig
JT  - Radiation oncology investigations
JID - 9437448
RN  - 4OC371KSTK (Uranium)
RN  - Q74S4N8N1G (Radon)
SB  - IM
MH  - Bronchi/*pathology
MH  - Bronchoscopy
MH  - Cells, Cultured
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Epithelium/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/etiology/*genetics/pathology
MH  - Mining
MH  - Molecular Biology
MH  - Ploidies
MH  - Precancerous Conditions/genetics/pathology
MH  - Radon/adverse effects
MH  - Risk Factors
MH  - Smoking/genetics/pathology
MH  - Trisomy
MH  - Uranium/adverse effects
EDAT- 1997/01/01 00:00
MHDA- 1997/09/26 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/09/26 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/(SICI)1520-6823(1997)5:3<103::AID-ROI3>3.0.CO;2-1 [doi]
PST - ppublish
SO  - Radiat Oncol Investig. 1997;5(3):103-5. doi: 
      10.1002/(SICI)1520-6823(1997)5:3<103::AID-ROI3>3.0.CO;2-1.