PMID- 9303338
OWN - NLM
STAT- MEDLINE
DCOM- 19971010
LR  - 20181201
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 114
IP  - 1
DP  - 1997 Sep
TI  - TAP1 and TAP2 genes in nickel allergy.
PG  - 94-6
AB  - The study was undertaken to see whether TAP1 and TAP2 (transporter associated 
      with antigen processing) genes are involved in susceptibility to nickel allergy. 
      The products of these genes are important in antigen transport and processing, 
      making them candidates for disease susceptibility. Fifty-five nickel-sensitive 
      and 54 non-sensitive subjects were TAP1- and TAP2-typed by amplification 
      refractory mutation system - polymerase chain reaction. The allele and phenotype 
      frequencies of TAP2B were significantly (p = 0.019 and 0.012, respectively) 
      increased in nickel-sensitive subjects versus controls. Relative risk (RR) for 
      TAP2B was 2.7 and etiological factor (EF) = 0.46. The allele frequency of TAP2C 
      was decreased among the nickel-sensitive subjects versus controls (p = 0.016). RR 
      for TAP2C was 0.18. In conclusion, TAP2B increases the risk for nickel allergy, 
      the results suggesting a considerably high EF.
FAU - Silvennoinen-Kassinen, S
AU  - Silvennoinen-Kassinen S
AD  - Department of Medical Microbiology, University of Oulu, Finland.
FAU - Ikaheimo, I
AU  - Ikaheimo I
FAU - Tiilikainen, A
AU  - Tiilikainen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Alleles
MH  - Antigen Presentation/genetics
MH  - Case-Control Studies
MH  - Dermatitis, Allergic Contact/*genetics/immunology
MH  - Gene Frequency
MH  - HLA Antigens/metabolism
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Humans
MH  - Nickel/*adverse effects
MH  - Phenotype
EDAT- 1997/09/26 00:00
MHDA- 1997/09/26 00:01
CRDT- 1997/09/26 00:00
PHST- 1997/09/26 00:00 [pubmed]
PHST- 1997/09/26 00:01 [medline]
PHST- 1997/09/26 00:00 [entrez]
AID - 10.1159/000237650 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1997 Sep;114(1):94-6. doi: 10.1159/000237650.