PMID- 9305416
OWN - NLM
STAT- MEDLINE
DCOM- 19971022
LR  - 20170214
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 11
IP  - 3
DP  - 1997
TI  - Effects of a specific CCK-A antagonist, Loxiglumide, on postprandial mood and 
      sleepiness.
PG  - 241-6
AB  - Previous studies have demonstrated that feelings of sleepiness increase after 
      ingestion of a fat-rich meal. The aim of the study was to test the hypothesis 
      that postprandial sleepiness is mediated by cholecystokinin (CCK) acting on CCK-A 
      receptors. A double-blind crossover study was conducted. Twelve male volunteers 
      ate a high-fat morning meal [54% energy fat, 41% energy carbohydrate (CHO)]. On 
      one day they received an i.v. infusion of Loxiglumide, a CCK-A receptor 
      antagonist (30 mg/kg/h for 10 min then 10 mg/kg/h for 3 h 10 min). On another day 
      the protocol was repeated except a saline placebo infusion was given at similar 
      rates as the Loxiglumide, starting 20 min before the meal. Subjects' mood and 
      sleepiness were monitored throughout using questionnaires and performance tasks. 
      The results indicate that ratings of vigour were significantly lower during the 
      Loxiglumide infusion than during the saline infusion, [F(1,10) = 6.65; p = 
      0.027]. Subjects who were infused with Loxiglumide on their first test day felt 
      significantly (p < 0.05) more fatigued, sleepy and tense and less vigorous, less 
      efficient and had lower energetic arousal during the Loxiglumide infusion than 
      during the saline infusion. In conclusion, the results suggest that the 
      postprandial decline in feelings of alertness after a fat-rich meal is not 
      mediated solely by CCK acting through CCK-A receptors.
FAU - Wells, A S
AU  - Wells AS
AD  - Centre for Human Nutrition, University of Sheffield, Northern General Hospital, 
      UK. A.S.Wells@Sheffield.ac.uk
FAU - Read, N W
AU  - Read NW
FAU - Fried, M
AU  - Fried M
FAU - Borovicka, J
AU  - Borovicka J
FAU - D'Amato, M
AU  - D'Amato M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Hormone Antagonists)
RN  - 0 (Receptor, Cholecystokinin A)
RN  - 0 (Receptors, Cholecystokinin)
RN  - 77MPX3N42I (loxiglumide)
RN  - EPL8W5565D (Proglumide)
SB  - IM
MH  - Adult
MH  - Affect/*drug effects/physiology
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Hormone Antagonists/*pharmacology
MH  - Humans
MH  - Male
MH  - Postprandial Period
MH  - Proglumide/*analogs & derivatives/pharmacology
MH  - Receptor, Cholecystokinin A
MH  - Receptors, Cholecystokinin/*antagonists & inhibitors
MH  - Sleep Stages/*drug effects/physiology
EDAT- 1997/01/01 00:00
MHDA- 1997/09/26 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/09/26 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1177/026988119701100307 [doi]
PST - ppublish
SO  - J Psychopharmacol. 1997;11(3):241-6. doi: 10.1177/026988119701100307.