PMID- 9306670
OWN - NLM
STAT- MEDLINE
DCOM- 19971021
LR  - 20190831
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 89
IP  - 1-2
DP  - 1997 Sep 19
TI  - Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy 
      users.
PG  - 111-28
AB  - Hair samples of 20 volunteers of the techno-music scene, who more or less 
      regularly consumed ecstasy tablets and speed and anonymously reported their abuse 
      history, were analyzed in one to seven 3 cm segments for amphetamine (A), 
      methamphetamine (MA), methylenedioxyamphetamine (MDA), 
      methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDE) and 
      N-methyl-1-(1,3-benzodioxol-5-yl)-2-butylamine (MBDB) by digestion in 1 M NaOH, 
      subsequent extraction with C18 Bond Elut columns, derivatization with 
      pentafluoropropionyl anhydride and GC/MS-SIM measurements using deuterated 
      standards of A, MA, MDA and MDMA. The concentrations were in the regions 0.1 to 
      4.8 ng/mg for A (17 samples), 0.05 to 0.89 ng/mg for MDA (16 samples), 0.1 to 8.3 
      ng/mg for MDMA (16 samples), 0.12 to 15 ng/mg for MDE (13 samples) and 0.21 to 
      1.3 ng/mg for MBDB (2 samples). MA was not detected. For comparison the frequency 
      and the concentration of these drugs in 124 different ecstasy tablets were 
      determined by HPLC. The drug concentration in the hair segments were compared 
      with the volunteers' reports. Despite the enormous interindividual differences 
      qualitatively an increase of the total concentration of MDA, MDMA and MDE in the 
      proximate 3 cm segments with increasing ecstasy abuse frequency during the last 
      three month before sampling is recognized. In the individual comparison with the 
      chronological consumer reports in most cases a longer interruption or a change of 
      the abuse intensity is not clearly seen at the segment concentrations. As a 
      reason the incorporation of the drugs from sweat into elder hair regions and the 
      slow removal by washing are discussed.
FAU - Rothe, M
AU  - Rothe M
AD  - Institute of Forensic Medicine, Humboldt-University, Berlin, Germany.
FAU - Pragst, F
AU  - Pragst F
FAU - Spiegel, K
AU  - Spiegel K
FAU - Harrach, T
AU  - Harrach T
FAU - Fischer, K
AU  - Fischer K
FAU - Kunkel, J
AU  - Kunkel J
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Hallucinogens)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine/*analysis/chemistry
MH  - Baths
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Hair Color
MH  - Hallucinogens/*analysis/chemistry
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/chemistry
MH  - Substance Abuse Detection/*methods
MH  - Substance-Related Disorders/*diagnosis
MH  - Time Factors
EDAT- 1997/10/27 00:00
MHDA- 1997/10/27 00:01
CRDT- 1997/10/27 00:00
PHST- 1997/10/27 00:00 [pubmed]
PHST- 1997/10/27 00:01 [medline]
PHST- 1997/10/27 00:00 [entrez]
AID - S0379-0738(97)00123-0 [pii]
AID - 10.1016/s0379-0738(97)00123-0 [doi]
PST - ppublish
SO  - Forensic Sci Int. 1997 Sep 19;89(1-2):111-28. doi: 10.1016/s0379-0738(97)00123-0.