PMID- 9309111
OWN - NLM
STAT- MEDLINE
DCOM- 19971015
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 98
IP  - 1
DP  - 1997 Oct 1
TI  - Assessment of chromosome 3 copy number in ocular melanoma using fluorescence in 
      situ hybridization.
PG  - 4-8
AB  - Recent reports have indicated that monosomy 3 is a marker of poor prognosis in 
      uveal melanoma. Fluorescence in situ hybridization (FISH) was performed on fresh 
      touch preparations from 17 uveal, and 5 conjunctival melanomas, using the 
      chromosome 3 centromeric probe, D3Z1. Of the 17 uveal melanomas, all of which 
      originated in the choroid, two cases revealed a monosomy of chromosome 3. One of 
      the conjunctival melanomas contained a major clone that was trisomic for 
      chromosome 3, and another conjunctival melanoma contained a tetrasomic 
      population. FISH, using the alpha-satellite probe for chromosome 3 on uveal 
      melanoma imprints, allows one to predict which patients are potentially at a 
      higher risk of relapse. Multiplication, rather than deletion, of copies of 
      chromosome 3 in conjunctival melanomas may be a nonspecific aberration, perhaps 
      indicative of polyploidy, a characteristic of tumor progression.
FAU - McNamara, M
AU  - McNamara M
AD  - Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
FAU - Felix, C
AU  - Felix C
FAU - Davison, E V
AU  - Davison EV
FAU - Fenton, M
AU  - Fenton M
FAU - Kennedy, S M
AU  - Kennedy SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid Neoplasms/*genetics/pathology
MH  - *Chromosomes, Human, Pair 3
MH  - Conjunctival Neoplasms/*genetics/pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*genetics/pathology
MH  - Middle Aged
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
AID - S0165460896004050 [pii]
AID - 10.1016/s0165-4608(96)00405-0 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Oct 1;98(1):4-8. doi: 10.1016/s0165-4608(96)00405-0.