PMID- 9309114
OWN - NLM
STAT- MEDLINE
DCOM- 19971015
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 98
IP  - 1
DP  - 1997 Oct 1
TI  - Fluorescence in situ hybridization assessment of the telomeric regions of jumping 
      translocations in a case of aggressive B-cell non-Hodgkin lymphoma.
PG  - 20-7
AB  - We report a jumping translocation involving a donor chromosome 1 long arm in a 
      case of aggressive B-cell non-Hodgkin lymphoma (NHL). Conventional cytogenetic 
      banding studies demonstrated a breakpoint distal to the heterochromatic region of 
      the donor 1q chromosome. Characterization by fluorescence in situ hybridization 
      (FISH) of the jumping translocation demonstrated an apparent telomeric sequence 
      loss of the recipient chromosomes. Additional cytogenetic aberrations, including 
      the t(18;22) translocation associated with non-Hodgkin lymphoma, were also 
      observed in this case. Cytogenetically similar cases of jumping translocations 
      reported in the literature have implicated a preferential involvement of the 
      donor chromosomes' heterochromatic regions and the telomeric regions of the 
      recipient chromosomes. Jumping translocations are still considered rare and their 
      appearance is associated with a poor prognosis. The presence of these specific 
      findings for this case are discussed and compared with those previously reported 
      in other hematologic disorders.
FAU - Gray, B A
AU  - Gray BA
AD  - Department of Pediatrics, University of Florida College of Medicine, Gainesville 
      32610-0296, USA.
FAU - Bent-Williams, A
AU  - Bent-Williams A
FAU - Wadsworth, J
AU  - Wadsworth J
FAU - Maiese, R L
AU  - Maiese RL
FAU - Bhatia, A
AU  - Bhatia A
FAU - Zori, R T
AU  - Zori RT
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 1
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics
MH  - Lymphoma, Follicular/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
AID - S0165460896004098 [pii]
AID - 10.1016/s0165-4608(96)00409-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Oct 1;98(1):20-7. doi: 
      10.1016/s0165-4608(96)00409-8.