PMID- 9310406
OWN - NLM
STAT- MEDLINE
DCOM- 19971106
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 765
IP  - 1
DP  - 1997 Aug 8
TI  - Dizocilpine (MK-801) increases not only dopamine but also serotonin and 
      norepinephrine transmissions in the nucleus accumbens as measured by 
      microdialysis in freely moving rats.
PG  - 149-58
AB  - The extracellular concentrations of dopamine (DA), norepinephrine (NE), and 
      serotonin (5-HT) in the nucleus accumbens (NACC) of freely moving rats were 
      monitored simultaneously via intracerebral microdialysis. Local infusion of the 
      non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 
      (dizocilpine) (5-250 microM) produced significant increases in extracellular 
      levels of DA, NE and 5-HT in a concentration-dependent fashion. Perfusion with 
      tetrodotoxin (TTX, 1 microM) blocked the ability of focal MK-801 (50 microM) to 
      increase DA, NE and 5-HT in the dialysate. Systemic administration of MK-801 (0.3 
      mg/kg, i.p.) also produced small, but statistically significant, increases in 
      extracellular concentrations of DA, NE and 5-HT in the NACC. Our microdialysis 
      results are consistent with the hypothesis that, in addition to dopaminergic, 
      serotonergic and noradrenergic neurotransmissions in the NACC are involved in the 
      mechanism by which MK-801 alters behavior in rats. Also, the present study gives 
      further support to the concept that NMDA receptors within the NACC do not 
      regulate DA release through direct excitatory control.
FAU - Yan, Q S
AU  - Yan QS
AD  - Department of Biomedical and Therapeutic Sciences, University of Illinois College 
      of Medicine at Peoria, 61656, USA.
FAU - Reith, M E
AU  - Reith ME
FAU - Jobe, P C
AU  - Jobe PC
FAU - Dailey, J W
AU  - Dailey JW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Dizocilpine Maleate/*pharmacology
MH  - Dopamine/*physiology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/drug effects
MH  - Norepinephrine/*physiology
MH  - Nucleus Accumbens/anatomy & histology/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*physiology
MH  - Synaptic Transmission/*drug effects
MH  - Tetrodotoxin/pharmacology
EDAT- 1997/08/08 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/08/08 00:00
PHST- 1997/08/08 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/08/08 00:00 [entrez]
AID - S0006-8993(97)00568-4 [pii]
AID - 10.1016/s0006-8993(97)00568-4 [doi]
PST - ppublish
SO  - Brain Res. 1997 Aug 8;765(1):149-58. doi: 10.1016/s0006-8993(97)00568-4.