PMID- 9311805
OWN - NLM
STAT- MEDLINE
DCOM- 19971020
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 71
IP  - 10
DP  - 1997 Oct
TI  - Retrovirus-induced target cell activation in the early phases of infection: the 
      mouse mammary tumor virus model.
PG  - 7295-9
AB  - Mouse mammary tumor virus (MMTV) infects B lymphocytes and expresses a 
      superantigen on the cell surface after integration of its reverse-transcribed 
      genome. Superantigen-dependent B- and T-cell activation becomes detectable 2 to 3 
      days after infection. We show here that before this event, B cells undergo a 
      polyclonal activation which does not involve massive proliferation. This first 
      phase of B-cell activation is T cell independent. Moreover, during the first 
      phase of activation, when only a small fraction of B cells is infected by 
      MMTV(SW), viral DNA is detected only in activated B cells. Such a B-cell 
      activation is also seen after injection of murine leukemia virus but not after 
      injection of vaccinia virus, despite the very similar kinetics and intensity of 
      the immune response. Since retroviruses require activated target cells to induce 
      efficient infection, these data suggest that the early polyclonal 
      retrovirus-induced target cell activation might play an important role in the 
      establishment of retroviral infections.
FAU - Ardavin, C
AU  - Ardavin C
AD  - Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, 
      Spain.
FAU - Luthi, F
AU  - Luthi F
FAU - Andersson, M
AU  - Andersson M
FAU - Scarpellino, L
AU  - Scarpellino L
FAU - Martin, P
AU  - Martin P
FAU - Diggelmann, H
AU  - Diggelmann H
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/*virology
MH  - DNA Replication
MH  - DNA, Viral/analysis/*biosynthesis
MH  - Female
MH  - Genome, Viral
MH  - Kinetics
MH  - Lymph Nodes/immunology/virology
MH  - *Lymphocyte Activation
MH  - Mammary Neoplasms, Experimental/*immunology/virology
MH  - Mammary Tumor Virus, Mouse/genetics/*immunology/pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred Strains
MH  - Mice, Nude
MH  - Milk/virology
MH  - Retroviridae Infections/*immunology
MH  - T-Lymphocytes/immunology/*virology
MH  - Time Factors
MH  - Tumor Virus Infections/*immunology
MH  - Virus Integration
MH  - Virus Replication
PMC - PMC192072
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
PMCR- 1997/10/01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
PHST- 1997/10/01 00:00 [pmc-release]
AID - 10.1128/JVI.71.10.7295-7299.1997 [doi]
PST - ppublish
SO  - J Virol. 1997 Oct;71(10):7295-9. doi: 10.1128/JVI.71.10.7295-7299.1997.