PMID- 9312981
OWN - NLM
STAT- MEDLINE
DCOM- 19971002
LR  - 20161124
IS  - 0870-399X (Print)
IS  - 0870-399X (Linking)
VI  - 10
IP  - 5
DP  - 1997 May
TI  - [Craniocerebral imaging in children with short stature].
PG  - 361-5
AB  - OBJECTIVE: To analyse the type and frequency of cranial CT and NMR imaging 
      anomalies in children of short stature. PATIENTS AND INTERVENTIONS: We studied 57 
      children of short stature with a mean age (+/-SD) of 10.1 +/- 3.8 years, 34 boys 
      and 23 girls, all of them with auxometric criteria of GH deficiency. After 
      studying the pituitary function and determination of karyotype in the girls, the 
      children were classified in to five groups:-Isolated GHD (IGHD) (n = 32), 
      multiple pituitary hormone deficiency (MPHD) (n = 6), neurosecretory dysfunction 
      (NSD) (n = 8), Turner syndrome (n = 7) and idiopathic short stature (ISS) (n = 
      4). The imaging methods used were cranial CT or NMR. RESULTS: Of the 57 children 
      studied the CT/NMR was abnormal in 37(64.9%) children. We found anomalies in 
      65.6% of IGHD patients, 62.5% of NSD patients, 100% of MPHD patients and 57.1% 
      and 25% in the Turner s. patients and ISS patients respectively. The most 
      frequent anomaly was hypoplastic pituitary found in 50% of IGHD patients, 37.5% 
      of NSD patients and 33.3% of MPHD patients. None of the cases of Turner s. or ISS 
      had hypoplastic pituitary. An empty sella was the second most frequent anomaly 
      found in 7 patients (IGHD-3, MPHD-3, DNS-1). Of the 25 children in which NMR was 
      performed, 8 had hypoplastic pituitary and stalk and 2 had interruption of the 
      pituitary stalk and ectopic neurohypophysis. CONCLUSION: These results strengthen 
      the necessity for CT/NMR imaging in children of short stature which, besides 
      allowing identification of tumors, also permits the diagnosis of idiopathic GHD 
      because of its frequent association with cranial imaging anomalies, mainly 
      hypoplastic pituitary.
FAU - Barros, L
AU  - Barros L
AD  - Departamento de Neuroradiologia, Hospitais da Universidade de Coimbra.
FAU - Ribeiro, C
AU  - Ribeiro C
FAU - Bastos, M
AU  - Bastos M
FAU - Rodrigues, D
AU  - Rodrigues D
FAU - Moura, C
AU  - Moura C
FAU - Geraldes, E
AU  - Geraldes E
FAU - Carvalheiro, M
AU  - Carvalheiro M
FAU - Fernandes, S
AU  - Fernandes S
FAU - Ruas, M M
AU  - Ruas MM
LA  - por
PT  - Journal Article
TT  - Imagiologia cranio-encefalica nas criancas com baixa estatura.
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
RN  - 0 (Pituitary Hormones)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - *Body Height
MH  - Brain/*diagnostic imaging/*pathology
MH  - Child
MH  - Female
MH  - Human Growth Hormone/deficiency
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Pituitary Hormones/deficiency
MH  - Skull/*diagnostic imaging/*pathology
MH  - Tomography, X-Ray Computed
MH  - Turner Syndrome/diagnosis
EDAT- 1997/05/01 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Acta Med Port. 1997 May;10(5):361-5.