PMID- 9313657
OWN - NLM
STAT- MEDLINE
DCOM- 19971023
LR  - 20190719
IS  - 0007-1331 (Print)
IS  - 0007-1331 (Linking)
VI  - 80
IP  - 3
DP  - 1997 Sep
TI  - Prognostic significance of microscopic vascularity for clear cell renal cell 
      carcinoma.
PG  - 401-4
AB  - OBJECTIVE: To investigate the association between tumour vascularity and patient 
      survival in a series of clear-cell renal cell carcinoma (RCC), which often 
      metastasizes via the vascular route and frequently has a prominent vascular 
      network. MATERIALS AND METHODS: Vessels were labelled in sections from 150 cases 
      of clear cell RCC by factor VIII immunohistochemistry. The mean microvessel 
      density (MMD), expressed as the number of vessels per 10 high-power fields (HPFs, 
      x400, aggregate field area 1.452 mm2) and tumour microvessel area (TMA), 
      expressed as the percentage of the total tumour area within 10 HPFs, were 
      measured for each case. The relationship between MMD and TMA, tumour stage and 
      grade, and patient survival over a 5-year follow-up was determined. RESULTS: 
      Tumour MMD ranged from 1 to 238 vessels per HPF, while the TMA was 1.2-60.8%. 
      There was a weak but significant difference for MMD between tumour grades (P < 
      0.01) and stages (P < 0.05). There was no significant association between TMA and 
      either tumour stage or grade. Division of cases according to MMD < or = 40 and > 
      40 per HPF showed a significant difference in survival curves between both 
      groups, with a higher MMD being associated with longer patient survival. The 
      significant association between MMD and survival was retained for stage 3 tumours 
      only when cases were stratified according to Robson's stage at presentation. TMA 
      did not correlate with survival. CONCLUSIONS: The assessment of tumour 
      vascularity is of prognostic significance for clear cell RCC. The significant 
      inverse relationship between MMD and patient survival suggests that for tumours 
      with a poor prognosis, decreased MMD is associated with tumour fibrosis and the 
      development of large diameter vascular channels.
FAU - Delahunt, B
AU  - Delahunt B
AD  - Department of Pathology, Wellington School of Medicine, University of Otago, New 
      Zealand.
FAU - Bethwaite, P B
AU  - Bethwaite PB
FAU - Thornton, A
AU  - Thornton A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Urol
JT  - British journal of urology
JID - 15740090R
SB  - IM
MH  - Adenocarcinoma, Clear Cell/*blood supply/mortality
MH  - Carcinoma, Renal Cell/*blood supply/mortality
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Neoplasms/*blood supply/mortality
MH  - Microcirculation
MH  - Neovascularization, Pathologic
MH  - Prognosis
MH  - Survival Rate
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
AID - 10.1046/j.1464-410x.1997.00374.x [doi]
PST - ppublish
SO  - Br J Urol. 1997 Sep;80(3):401-4. doi: 10.1046/j.1464-410x.1997.00374.x.