PMID- 9313888
OWN - NLM
STAT- MEDLINE
DCOM- 19971028
LR  - 20051117
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 20
IP  - 6
DP  - 1997 Sep
TI  - Autologous GVHD following PBSCT, with evidence for a graft-versus-myeloma effect.
PG  - 517-20
AB  - The development of GVHD following allogeneic BMT is known to be closely 
      associated with significant antileukaemic activity. Immunological 
      graft-versus-leukaemia (GVL) effects are now well established and are commonly 
      exploited in the treatment of leukaemic relapse following allogeneic 
      transplantation by the use of donor lymphocyte infusions. More recently a 
      graft-versus-myeloma (GVM) effect following allogeneic transplantation has been 
      documented, suggesting that eradication of haematological malignancies following 
      allogeneic transplantation is achieved at least in part by immunological 
      mechanisms. It is now also established that spontaneous GVHD can occur following 
      autologous transplantation and can be induced by cyclosporin A administration. 
      However, there is only limited evidence that the development of autologous GVHD 
      has an antitumour effect. We report for the first time the development of 
      autologous GVHD following PBSC transplantation for myeloma apparently resulting 
      in a GVM effect.
FAU - Byrne, J L
AU  - Byrne JL
AD  - Department of Haematology, City Hospital Nottingham, UK.
FAU - Carter, G I
AU  - Carter GI
FAU - Ellis, I
AU  - Ellis I
FAU - Haynes, A P
AU  - Haynes AP
FAU - Russell, N H
AU  - Russell NH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (Antigens, CD34)
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Antigens, CD34/analysis
MH  - Cell Movement
MH  - Graft vs Host Disease/drug therapy/etiology/*pathology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunoglobulin kappa-Chains/urine
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/drug therapy/*pathology/*therapy
MH  - Plasma Cells/pathology
MH  - Transplantation, Autologous
EDAT- 1997/10/06 00:00
MHDA- 1997/10/06 00:01
CRDT- 1997/10/06 00:00
PHST- 1997/10/06 00:00 [pubmed]
PHST- 1997/10/06 00:01 [medline]
PHST- 1997/10/06 00:00 [entrez]
AID - 10.1038/sj.bmt.1700922 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 1997 Sep;20(6):517-20. doi: 10.1038/sj.bmt.1700922.