PMID- 9314640
OWN - NLM
STAT- MEDLINE
DCOM- 19980116
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 20
IP  - 10
DP  - 1997 Oct
TI  - Total plasma antioxidant capacity predicts thrombosis-prone status in NIDDM 
      patients.
PG  - 1589-93
AB  - OBJECTIVE: To explore the hypothesis that a relationship exists between free 
      radical activity and abnormalities in hemostasis in NIDDM. RESEARCH DESIGN AND 
      METHODS: The use of the total radical-trapping antioxidant parameter (TRAP) has 
      very recently been proposed to explore the antioxidant property of a plasma and 
      their mutual cooperation. In the present study, TRAP, vitamin E, vitamin C, 
      vitamin A, uric acid, protein-bound SH (thiol) groups, fibrinogen, prothrombin 
      fragments F1 + 2, and D-dimer have been evaluated in 46 NIDDM patients and 47 
      healthy matched control subjects. RESULTS: In NIDDM patients, TRAP, vitamin A, SH 
      groups, and uric acid were significantly reduced, whereas the level of vitamin E 
      was significantly increased. Vitamin C was similar in the two groups. Fibrinogen, 
      prothrombin fragment 1 + 2, and D-dimer were increased in diabetic patients. 
      TRAP, but no single other antioxidant, had a strong inverse association with 
      fibrinogen, prothrombin fragment 1 + 2, and D-dimer. CONCLUSIONS: These findings 
      are consistent with the hypothesis that oxidative stress may condition 
      coagulation activation in diabetics. However, the data suggest that it is the 
      total antioxidant capacity rather than any single plasma antioxidant that is the 
      most relevant parameter.
FAU - Ceriello, A
AU  - Ceriello A
AD  - Department of Medicine and Pathology, Clinical and Experimental, University of 
      Udine, Italy.
FAU - Bortolotti, N
AU  - Bortolotti N
FAU - Pirisi, M
AU  - Pirisi M
FAU - Crescentini, A
AU  - Crescentini A
FAU - Tonutti, L
AU  - Tonutti L
FAU - Motz, E
AU  - Motz E
FAU - Russo, A
AU  - Russo A
FAU - Giacomello, R
AU  - Giacomello R
FAU - Stel, G
AU  - Stel G
FAU - Taboga, C
AU  - Taboga C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Antioxidants)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 0 (fibrin fragment D)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 268B43MJ25 (Uric Acid)
RN  - 72270-84-9 (prothrombin fragment 1)
RN  - 78768-79-3 (prothrombin fragment 2)
RN  - 9001-26-7 (Prothrombin)
RN  - 9001-32-5 (Fibrinogen)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Antioxidants/*analysis
MH  - Ascorbic Acid/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diabetic Angiopathies/*epidemiology
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis
MH  - Fibrinogen/analysis
MH  - Hemostasis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptide Fragments/analysis
MH  - Predictive Value of Tests
MH  - Protein Precursors/analysis
MH  - Prothrombin/analysis
MH  - Reference Values
MH  - Regression Analysis
MH  - Risk Factors
MH  - Thrombosis/*epidemiology
MH  - Uric Acid/blood
MH  - Vitamin A/blood
MH  - Vitamin E/blood
EDAT- 1997/10/07 00:00
MHDA- 1997/10/07 00:01
CRDT- 1997/10/07 00:00
PHST- 1997/10/07 00:00 [pubmed]
PHST- 1997/10/07 00:01 [medline]
PHST- 1997/10/07 00:00 [entrez]
AID - 10.2337/diacare.20.10.1589 [doi]
PST - ppublish
SO  - Diabetes Care. 1997 Oct;20(10):1589-93. doi: 10.2337/diacare.20.10.1589.