PMID- 9315383
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20190826
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 24
IP  - 9-10
DP  - 1997 Sep-Oct
TI  - Supramedullary modulation of sympathetic vasomotor function.
PG  - 748-54
AB  - 1. Supramedullary structures including the ventral medial prefrontal cortex 
      (MPFC) and the midbrain cuneiform nucleus (CnF) project directly and indirectly 
      to premotor sympatho-excitatory neurons of the rostral ventrolateral medulla 
      (RVLM) that are critically involved in the generation of sympathetic vasomotor 
      tone. 2. Electrophysiological studies have demonstrated that activation of 
      depressor sites within the MPFC is associated with splanchnic sympathetic 
      vasomotor inhibition and inhibition of the activity of RVLM sympathoexcitatory 
      neurons. 3. Antidromic mapping and anatomical studies support the notion that a 
      relay in the nucleus tractus solitarius is involved in the cardiovascular 
      response to MPFC stimulation. 4. The midbrain CnF, which lies adjacent to the 
      midbrain periaqueductal grey, is a sympathoexcitatory region of the midbrain 
      reticular formation. Sympathoexcitatory responses evoked from the CnF are 
      associated with short-latency excitation of RVLM neurons. 5. Cuneiform nucleus 
      stimulation induces the expression of mRNA for the immediate early genes c-fos 
      and NGFI-A in mid-brain, pontine and hypothalamic structures. 6. The MPFC and CnF 
      are supramedullary structures with opposing modulatory influences on sympathetic 
      vasomotor drive, whose roles in cardiovascular control mechanisms warrant further 
      investigation.
FAU - Verberne, A J
AU  - Verberne AJ
AD  - University of Melbourne, Department of Medicine, Victoria, Australia. 
      tonyv@austin.unimelb.edu.au
FAU - Lam, W
AU  - Lam W
FAU - Owens, N C
AU  - Owens NC
FAU - Sartor, D
AU  - Sartor D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Autonomic Pathways/physiology
MH  - Humans
MH  - Medulla Oblongata/*physiology
MH  - Muscle, Smooth, Vascular/innervation/*physiology
MH  - Neurotransmitter Agents/*physiology
MH  - Sympathetic Nervous System/*physiology
RF  - 80
EDAT- 1997/10/07 00:00
MHDA- 1997/10/07 00:01
CRDT- 1997/10/07 00:00
PHST- 1997/10/07 00:00 [pubmed]
PHST- 1997/10/07 00:01 [medline]
PHST- 1997/10/07 00:00 [entrez]
AID - 10.1111/j.1440-1681.1997.tb02126.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1997 Sep-Oct;24(9-10):748-54. doi: 
      10.1111/j.1440-1681.1997.tb02126.x.