PMID- 9315548
OWN - NLM
STAT- MEDLINE
DCOM- 19971023
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 96
IP  - 5
DP  - 1997 Sep 2
TI  - Body-surface distribution of changes in activation-recovery intervals before and 
      after catheter ablation in patients with Wolff-Parkinson-White syndrome: clinical 
      evidence for ventricular 'electrical remodeling' with prolongation of 
      action-potential duration over a preexcited area.
PG  - 1566-74
AB  - BACKGROUND: T-wave abnormalities after catheter ablation in patients with 
      manifest Wolff-Parkinson-White (WPW) syndrome have been attributed to a 
      continuation of repolarization abnormalities induced by preexcitation (cardiac 
      memory). METHODS AND RESULTS: To clarify changes in repolarization properties, we 
      analyzed the activation-recovery interval (ARI) obtained from body-surface maps 
      and the relationship between the activation time (AT) and ARI in 30 patients with 
      WPW syndrome (group A, 18 patients with manifest left-sided accessory pathway; 
      group B, 7 patients with manifest right-sided accessory pathway; and group C, 5 
      patients with concealed left-sided accessory pathway) before, 1 day after, and 1 
      week after ablation. The ARI significantly decreased 1 week after ablation 
      compared with before and 1 day after ablation over the preexcited area in groups 
      A and B. Correlation coefficients between the AT and ARI showed a significantly 
      (P<.01) stronger inverse relationship before (r=-.58) and 1 week after (r=-.64) 
      ablation than 1 day after ablation (r=-.46) in groups A and B. In group C, the 
      ARI and correlation coefficients between the AT and ARI showed no significant 
      changes. CONCLUSIONS: These findings suggest a prolongation of the 
      action-potential duration over the preexcited area before and just after ablation 
      as ventricular "electrical remodeling," a decrease in the inverse relationship 
      between the AT and action-potential duration 1 day after ablation, and a gradual 
      recovery of the action-potential duration over the preexcited area and inverse 
      relationship 1 week after ablation.
FAU - Akahoshi, M
AU  - Akahoshi M
AD  - First Department of Internal Medicine, University of Nagoya School of Medicine, 
      Japan.
FAU - Hirai, M
AU  - Hirai M
FAU - Inden, Y
AU  - Inden Y
FAU - Sano, H
AU  - Sano H
FAU - Shimizu, A
AU  - Shimizu A
FAU - Kondo, T
AU  - Kondo T
FAU - Makino, M
AU  - Makino M
FAU - Horiba, M
AU  - Horiba M
FAU - Yoshida, Y
AU  - Yoshida Y
FAU - Tsuboi, N
AU  - Tsuboi N
FAU - Hirayama, H
AU  - Hirayama H
FAU - Ito, T
AU  - Ito T
FAU - Hayashi, H
AU  - Hayashi H
FAU - Saito, H
AU  - Saito H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Action Potentials
MH  - Adult
MH  - Body Surface Potential Mapping
MH  - *Catheter Ablation
MH  - Electrocardiography
MH  - Electrophysiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reaction Time
MH  - Wolff-Parkinson-White Syndrome/*physiopathology/*surgery
EDAT- 1997/10/07 00:00
MHDA- 1997/10/07 00:01
CRDT- 1997/10/07 00:00
PHST- 1997/10/07 00:00 [pubmed]
PHST- 1997/10/07 00:01 [medline]
PHST- 1997/10/07 00:00 [entrez]
AID - 10.1161/01.cir.96.5.1566 [doi]
PST - ppublish
SO  - Circulation. 1997 Sep 2;96(5):1566-74. doi: 10.1161/01.cir.96.5.1566.