PMID- 9316297
OWN - NLM
STAT- MEDLINE
DCOM- 19971106
LR  - 20190914
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 39
IP  - 4
DP  - 1997 Aug
TI  - Hypercalcemia in children: an overview.
PG  - 479-84
AB  - Hypercalcemia occurs in children of all ages. A serum calcium level over 15 mg/dL 
      can be life-threatening. The association between familial hypocalciuric 
      hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NHPT) has been 
      discussed. FHH is characterized by a high serum calcium concentration, relatively 
      low urine calcium excretion, and an inappropriately normal parathyroid hormone 
      (PTH) concentration. On the other hand, NHPT is a rare disease characterized by 
      markedly increased serum calcium (15 mg/dL) and PTH concentrations, and is fatal 
      without parathyroidectomy early in life. Recently, a complementary DNA encoding 
      an extracellular calcium-sensing receptor has been isolated. Furthermore, three 
      mutations in the receptor gene in FHH and NHPT individuals have been described. 
      Thus, heterozygotes and homozygotes of FHH may have an intermittent hypercalcemia 
      and NHPT, respectively. Vitamin D-related hypercalcemia, and vitamin D 
      intoxication and immobilization are also discussed.
FAU - Nishiyama, S
AU  - Nishiyama S
AD  - Department of Pediatrics, School of Medicine, Kumamoto University, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 0 (Calcium-Binding Proteins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Calcium-Binding Proteins/genetics
MH  - Child
MH  - Humans
MH  - *Hypercalcemia/etiology/genetics/physiopathology
MH  - Hyperparathyroidism/complications
MH  - Infant
MH  - Osteogenesis
MH  - Vitamin D/metabolism
RF  - 30
EDAT- 1997/08/01 00:00
MHDA- 1997/10/08 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/10/08 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1111/j.1442-200x.1997.tb03624.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1997 Aug;39(4):479-84. doi: 
      10.1111/j.1442-200x.1997.tb03624.x.