PMID- 9316645
OWN - NLM
STAT- MEDLINE
DCOM- 19971027
LR  - 20220330
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 52
IP  - 3
DP  - 1997 Oct 24
TI  - Comparison of the effects of various fine particles on IgE antibody production in 
      mice inhaling Japanese cedar pollen allergens.
PG  - 231-48
AB  - The adjuvant effects of various fine particles [Kanto loam dust, fly ash, carbon 
      black, diesel exhaust particles (DEP), and aluminum hydroxide (alum)] on 
      immunoglobulin E (IgE) antibody production in female BDF1 mice were examined. In 
      experiment 1, animals both received 25 micrograms of each particle intranasally 
      and were exposed to aerosolized Japanese cedar pollen allergens (JCPA) for 30 
      min/d at 1-wk intervals for the first 8 wk. This was followed by exposure for 30 
      min every 3 wk for the next 9 wk. As parameters of allergic rhinitis, 
      measurements were made of JCPA-specific IgE and IgG antibody titers, the 
      protein-adsorbing capacity of each type of particle, and nasal rubbing movements. 
      The increases in anti-JCPA IgE and IgG antibody production in mice treated with 
      aerosolized JCPA plus respective particles were significantly greater than that 
      found with aerosolized JCPA alone. This was associated with no marked differences 
      in the other allergic rhinitis parameters. In experiment 2, after the 
      administration of particles as in experiment 1, about 160,000 grains of Japanese 
      cedar pollen (JCP, native dry pollen) were dropped onto the tip of the nose of 
      mice twice a week for 16 wk. Six weeks after the first immunization, the 
      anti-JCPA IgE antibody titers of groups treated with the respective particles 
      were greater than 1:20, whereas those of mice treated with JCP alone were 1:10. 
      No significant differences in the anti-JCPA IgE and IgG antibody productions, 
      nasal rubbing counts, or histopathological changes were observed after 18 wk. 
      These results suggested the nature of the particles, their capacity to adsorb 
      antigens, and/or their size may not be related to enhancement of IgG antibody 
      production nor symptoms of allergic rhinitis. However, IgE antibody production 
      seemed to occur earlier in mice treated with particles than in mice immunized 
      with allergens alone.
FAU - Maejima, K
AU  - Maejima K
AD  - Japan Automobile Research Institute, Ibaraki, Japan. kmae@jari.or.jp
FAU - Tamura, K
AU  - Tamura K
FAU - Taniguchi, Y
AU  - Taniguchi Y
FAU - Nagase, S
AU  - Nagase S
FAU - Tanaka, H
AU  - Tanaka H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Cry j I protein, Cryptomeria japonica)
RN  - 0 (Cry j II protein, Cryptomeria japonica)
RN  - 0 (Dust)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Plant Proteins)
RN  - 0 (Vehicle Emissions)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 5QB0T2IUN0 (Aluminum Hydroxide)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Administration, Inhalation
MH  - Administration, Intranasal
MH  - Allergens/*administration & dosage/immunology
MH  - Aluminum Hydroxide
MH  - Animals
MH  - Antigens, Plant
MH  - Behavior, Animal/drug effects
MH  - Carbon
MH  - Dust
MH  - Female
MH  - Immunization
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/*biosynthesis
MH  - Japan
MH  - Mast Cells/immunology
MH  - Mice
MH  - Nasal Mucosa/drug effects/pathology
MH  - Particle Size
MH  - Passive Cutaneous Anaphylaxis/immunology
MH  - Plant Proteins/*administration & dosage/immunology
MH  - *Pollen
MH  - Rhinitis, Allergic, Perennial/immunology
MH  - Trees
MH  - Vehicle Emissions
EDAT- 1997/10/08 00:00
MHDA- 1997/10/08 00:01
CRDT- 1997/10/08 00:00
PHST- 1997/10/08 00:00 [pubmed]
PHST- 1997/10/08 00:01 [medline]
PHST- 1997/10/08 00:00 [entrez]
AID - 10.1080/00984109708984062 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1997 Oct 24;52(3):231-48. doi: 
      10.1080/00984109708984062.