PMID- 9322223
OWN - NLM
STAT- MEDLINE
DCOM- 19971113
LR  - 20191102
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 2
IP  - 5
DP  - 1997 Sep
TI  - The transforming growth factor alpha gene family is involved in the 
      neuroendocrine control of mammalian puberty.
PG  - 355-8
AB  - The concept is proposed that the central control of mammalian female puberty 
      requires the interactive participation of neuronal networks and glial cells of 
      the astrocytic lineage. According to this concept neurons and astrocytes control 
      the pubertal process by regulating the secretory activity of those neurons that 
      secrete luteinizing hormone-releasing hormone (LHRH). LHRH, in turn, governs 
      sexual development by stimulating the secretion of pituitary gonadotropins. 
      Astrocytes affect LHRH neuronal function via a cell-cell signaling mechanism 
      involving several growth factors and their corresponding receptors. Our 
      laboratory has identified two members of the epidermal growth factor/transforming 
      growth factor (EGF/TGF alpha) family as components of the glial-neuronal 
      interactive process that regulates LHRH secretion. Transforming growth factor 
      alpha (TGF alpha) and its distant congener neu-differentiation factor, NDF, are 
      produced in hypothalamic astrocytes and stimulate LHRH release via a glial 
      intermediacy. The actions of TGF alpha and NDF on hypothalamic astrocytes involve 
      the interactive activation of their cognate receptors and the synergistic effect 
      of both ligands in stimulating the glial release of prostaglandin E2 (PGE2). In 
      turn, PGE2 acts directly on LHRH neurons to stimulate LHRH release. A variety of 
      experimental approaches has led to the conclusion that both TGF alpha and NDF are 
      physiological components of the central mechanism controlling the initiation of 
      female puberty.
FAU - Ojeda, S R
AU  - Ojeda SR
AD  - Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 
      97006, USA. ojedas@ohsu.edu
FAU - Ma, Y J
AU  - Ma YJ
FAU - Rage, F
AU  - Rage F
LA  - eng
GR  - HD25123/HD/NICHD NIH HHS/United States
GR  - P30 HD18185/HD/NICHD NIH HHS/United States
GR  - RR00163/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects
MH  - Female
MH  - Neuroglia/drug effects
MH  - Neurons/*drug effects
MH  - Transforming Growth Factor alpha/*genetics/pharmacology
RF  - 41
EDAT- 1997/10/10 00:00
MHDA- 1997/10/10 00:01
CRDT- 1997/10/10 00:00
PHST- 1997/10/10 00:00 [pubmed]
PHST- 1997/10/10 00:01 [medline]
PHST- 1997/10/10 00:00 [entrez]
AID - 10.1038/sj.mp.4000307 [doi]
PST - ppublish
SO  - Mol Psychiatry. 1997 Sep;2(5):355-8. doi: 10.1038/sj.mp.4000307.