PMID- 9324065
OWN - NLM
STAT- MEDLINE
DCOM- 19971024
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 61
IP  - 13
DP  - 1997
TI  - Spirulina platensis inhibits anaphylactic reaction.
PG  - 1237-44
AB  - We investigated the effects of the powders of Spirulina platensis (SPP) on 
      anaphylactic reactions. SPP inhibited compound 48/80-induced anaphylactic shock 
      100% with doses of 0.5, and 1.0 mg/g body weight (BW). SPP significantly 
      inhibited serum histamine levels induced by compound 48/80 in rats. SPP (0.5 mg/g 
      BW) inhibited to 68.7% passive cutaneous anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE. SPP dose-dependently inhibited the histamine 
      release from the rat peritoneal mast cells (RPMC) by compound 48/80. Moreover, 
      SPP had a significant effect on anti-DNP IgE-induced histamine release or tumor 
      necrosis factor-alpha production from RPMC. These results suggest that SPP may 
      contain compounds with actions that inhibit mast cell degranulation in the rat.
FAU - Yang, H N
AU  - Yang HN
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Ikasn, 
      Chonbuk, South Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Dinitrophenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Cell Degranulation
MH  - Cyanobacteria/*physiology
MH  - Dinitrophenols/immunology
MH  - Histamine/blood
MH  - Histamine Release/immunology
MH  - Immunoglobulin E/immunology
MH  - *Passive Cutaneous Anaphylaxis/immunology
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1997/01/01 00:00
MHDA- 1997/11/04 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/11/04 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0024320597006681 [pii]
AID - 10.1016/s0024-3205(97)00668-1 [doi]
PST - ppublish
SO  - Life Sci. 1997;61(13):1237-44. doi: 10.1016/s0024-3205(97)00668-1.