PMID- 9324134
OWN - NLM
STAT- MEDLINE
DCOM- 19971021
LR  - 20190627
IS  - 0002-9610 (Print)
IS  - 0002-9610 (Linking)
VI  - 174
IP  - 3
DP  - 1997 Sep
TI  - Tracking the MEN1 gene.
PG  - 266-70
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant 
      disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, 
      and pituitary adenomas. Sporadic forms of these tumors are more common than their 
      inherited counterparts and share common genetic abnormalities. We have been 
      studying the molecular genetics of sporadic pancreatic endocrine tumors to 
      identify the tumor suppressor gene responsible for MEN1 by positional cloning. 
      This review introduces the reader to the fundamentals of these molecular genetic 
      techniques and outlines the general strategy used to isolate this gene.
FAU - Ebrahimi, S A
AU  - Ebrahimi SA
AD  - Department of Surgery, West Los Angeles Veterans Affairs Medical Center, and the 
      University of California, Los Angeles, School of Medicine, USA.
FAU - Sawicki, M P
AU  - Sawicki MP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - *Cloning, Molecular
MH  - DNA Mutational Analysis
MH  - Gene Library
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - Pancreatic Neoplasms/*genetics
RF  - 23
EDAT- 1997/10/27 00:00
MHDA- 1997/10/27 00:01
CRDT- 1997/10/27 00:00
PHST- 1997/10/27 00:00 [pubmed]
PHST- 1997/10/27 00:01 [medline]
PHST- 1997/10/27 00:00 [entrez]
AID - S0002961097001438 [pii]
AID - 10.1016/s0002-9610(97)00143-8 [doi]
PST - ppublish
SO  - Am J Surg. 1997 Sep;174(3):266-70. doi: 10.1016/s0002-9610(97)00143-8.