PMID- 9327077
OWN - NLM
STAT- MEDLINE
DCOM- 19971114
LR  - 20190831
IS  - 0271-3586 (Print)
IS  - 0271-3586 (Linking)
VI  - 32
IP  - 5
DP  - 1997 Nov
TI  - No evidence for the influence of HLA class II in alleles in isocyanate-induced 
      asthma.
PG  - 522-7
AB  - Isocyanates are one of the main causes of occupational asthma. The aim of this 
      investigation was to study the possible genetic background of isocyanate-induced 
      asthma under consideration of the atopy status and different lung function 
      parameters. We investigated the human leukocyte antigen (HLA) genes DRB1,3,4,5, 
      DQB1, and DQA1 in 55 isocyanate-exposed patients with workplace-related dyspnea 
      (32 asthmatics, 23 nonasthmatics) and 90 nonexposed controls. In contrast to 
      other studies, we found no significant differences for any HLA class II allele 
      tested in our study group. Furthermore, no significant differences concerning the 
      aspartic amino acid residue 57 of DQB1 was observed. Therefore, we are unable to 
      confirm an involvement of a specific HLA class II allele or DQB1-Asp57 in 
      conferring susceptibility to isocyanate asthma in our study group.
FAU - Rihs, H P
AU  - Rihs HP
AD  - Institute of Occupational Medicine (BGFA), Ruhr-University Bochum, Germany. 
      rihs@bgfa.ruhr-uni-bochum.de
FAU - Barbalho-Krolls, T
AU  - Barbalho-Krolls T
FAU - Huber, H
AU  - Huber H
FAU - Baur, X
AU  - Baur X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Ind Med
JT  - American journal of industrial medicine
JID - 8101110
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Isocyanates)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/chemically induced/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - HLA-DQ Antigens/*physiology
MH  - HLA-DR Antigens/*physiology
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Isocyanates/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
MH  - Phenotype
MH  - Respiratory Function Tests
EDAT- 1997/11/05 15:31
MHDA- 2000/06/20 09:00
CRDT- 1997/11/05 15:31
PHST- 1997/11/05 15:31 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/11/05 15:31 [entrez]
AID - 10.1002/(SICI)1097-0274(199711)32:5<522::AID-AJIM13>3.0.CO;2-4 [pii]
AID - 10.1002/(sici)1097-0274(199711)32:5<522::aid-ajim13>3.0.co;2-4 [doi]
PST - ppublish
SO  - Am J Ind Med. 1997 Nov;32(5):522-7. doi: 
      10.1002/(sici)1097-0274(199711)32:5<522::aid-ajim13>3.0.co;2-4.