PMID- 9327193
OWN - NLM
STAT- MEDLINE
DCOM- 19971106
LR  - 20190909
IS  - 0300-7995 (Print)
IS  - 0300-7995 (Linking)
VI  - 13
IP  - 10
DP  - 1997
TI  - An open, parallel group comparison of quinapril and captopril, when added to 
      diuretic therapy, in the treatment of elderly patients with heart failure.
PG  - 583-92
AB  - This study aimed to compare the efficacy, tolerability and first-dose 
      blood-pressure response of once-daily quinapril and twice-daily captopril when 
      added to diuretic therapy in elderly patients with heart failure. The study was 
      performed at a single centre as an open randomised parallel-group study, patients 
      being selected for inclusion from the outpatient population. Following a starting 
      dose of either 2.5 mg once-daily quinapril, or 6.25 mg twice-daily captopril, 
      patients were reviewed at two-weekly intervals, and following clinical assessment 
      a decision was made either to titrate up to the next medication stage or to enter 
      the patient into the 16-week maintenance phase. Efficacy was assessed using a 
      six-minute walking test, the New York Heart Association (NYHA) class, a 
      functional lifescale (FLS) questionnaire and the cardiothoracic ratio (CTR)-at 
      study entry and at the end of the maintenance phase. Blood pressure was measured 
      for 5 h post-first-dose of medication. Sixty-one patients were randomised to 
      treatment: 30 to quinapril and 31 to captopril. Following withdrawals, data from 
      36 patients (20 on quinapril, 16 on captopril) were available for analysis. The 
      distance walked during the six-minute walking test improved in both groups; the 
      difference between the treatment groups was not statistically significant. There 
      were no significant changes in the FLS or CTR. An analysis of change in the NYHA 
      status from study entry to study end showed a statistically significant 
      difference between the two groups (p = 0.02) in favour of quinapril. Five 
      patients in each group experienced hypotension during the 5 h following the first 
      dose of medication. This study has shown heart failure to be as well controlled 
      by once-daily quinapril as by twice-daily captopril, with comparable effects on 
      first-dose blood-pressure response.
FAU - Beynon, J H
AU  - Beynon JH
AD  - Department of Geriatric Medicine, St. Woolos Hospital, Newport, UK.
FAU - Pathy, M S
AU  - Pathy MS
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Isoquinolines)
RN  - 0 (Tetrahydroisoquinolines)
RN  - 9G64RSX1XD (Captopril)
RN  - RJ84Y44811 (Quinapril)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Antihypertensive Agents/*therapeutic use
MH  - Blood Pressure/drug effects
MH  - Captopril/*therapeutic use
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Isoquinolines/*therapeutic use
MH  - Male
MH  - Quinapril
MH  - Severity of Illness Index
MH  - *Tetrahydroisoquinolines
MH  - Walking
EDAT- 1997/01/01 00:00
MHDA- 1997/11/04 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/11/04 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1185/03007999709113332 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 1997;13(10):583-92. doi: 10.1185/03007999709113332.