PMID- 932833
OWN - NLM
STAT- MEDLINE
DCOM- 19760901
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 106
IP  - 7
DP  - 1976 Jul
TI  - Differential effects of high dietary levels of vitamin A on the vitamin 
      E-selenium nutrition of young and adult chickens.
PG  - 967-75
AB  - Experiments were conducted to determine the nature of the interaction of high 
      levels of vitamin A and vitamin E-selenium nutrition in the chicken. Results 
      showed that chicks were protected from the vitamin E-selenium deficiency disease 
      exudative diathesis (ED) by a high dietary level of vitamin A (1.0 X 10(6) IU/kg) 
      which moderately depressed growth. A greater concentration (1.5 X 10(6) IU/kg) of 
      vitamin A in the diets of hens fed a low vitamin E diet hastened their depletion 
      of plasma tocopherols and increased plasma glutathione peroxidase (GSH-px) 
      activity. At hatching the progeny of vitamin A-fed hens were severely depleted of 
      plasma tocopherols but had normal plasma GSH-px activities. They showed increased 
      susceptibility to ED when fed selenium-deficient, vitamin E-free diets for 2 
      weeks. Absorption studies using ligated duodenal loops or oral doses indicated 
      that high-level dietary vitamin A promoted the enteric absorption of selenium but 
      interfered with the absorption of vitamin E. The dual nature of these effects was 
      related to the ED-protective influence of vitamin A when fed to chicks, and the 
      ED-stimulative influence on progeny when vitamin A was fed to dams.
FAU - Combs, G F Jr
AU  - Combs GF Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Body Weight
MH  - Chickens/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Oviposition/drug effects
MH  - *Selenium/metabolism/pharmacology
MH  - *Vitamin A/adverse effects/metabolism
MH  - *Vitamin E/metabolism/pharmacology
MH  - Vitamin E Deficiency/etiology/metabolism/physiopathology
EDAT- 1976/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1976/07/01 00:00
PHST- 1976/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1976/07/01 00:00 [entrez]
AID - 10.1093/jn/106.7.967 [doi]
PST - ppublish
SO  - J Nutr. 1976 Jul;106(7):967-75. doi: 10.1093/jn/106.7.967.