PMID- 9328790
OWN - NLM
STAT- MEDLINE
DCOM- 19971212
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 55
IP  - 1
DP  - 1997 Jun
TI  - HLA class I and class II allele and haplotype distribution in the Venezuelan 
      population.
PG  - 53-8
AB  - Population studies represent an integral part, and a necessary link in a complex 
      chain of host-pathogen interactions, disease pathogenesis, and major 
      histocompatibility complex polymorphism. HLA class I and class II allele and 
      haplotype distributions among Venezuelan mestizos were determined. Genes of 
      Mongoloid, Negroid, and Caucasoid origin have created a distinctive human 
      leukocyte antigen (HLA) genetic profile in this hybrid mestizo population that 
      will influence HLA and disease association studies. The predominant HLA-B DQA1 
      DQB1 DRB1 haplotype is HLA-B44 DQA1*0201 DQB1*0201 DRB1*0701 (5.3%). It is 
      noteworthy that the HLA-A3 B7 DR2 and the HLA-A1 B8 DR3 linkage groups, which are 
      part of conserved or ancestral haplotypes, the last one associated with a wide 
      range of autoimmune diseases and immune abnormalities in apparently healthy 
      subjects, show low incidence among Venezuelan mestizos. This fact may be useful 
      for future HLA and disease association studies and for localization of genes 
      involved in immune regulation associated with these haplotypes.
FAU - Makhatadze, N J
AU  - Makhatadze NJ
AD  - Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela.
FAU - Franco, M T
AU  - Franco MT
FAU - Layrisse, Z
AU  - Layrisse Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Black People/genetics
MH  - Female
MH  - *Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Venezuela
MH  - White People/genetics
EDAT- 1997/06/01 00:00
MHDA- 1997/11/05 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/11/05 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0198-8859(97)00088-8 [pii]
AID - 10.1016/s0198-8859(97)00088-8 [doi]
PST - ppublish
SO  - Hum Immunol. 1997 Jun;55(1):53-8. doi: 10.1016/s0198-8859(97)00088-8.