PMID- 9331483
OWN - NLM
STAT- MEDLINE
DCOM- 19971210
LR  - 20191210
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 87
IP  - 2
DP  - 1997 Sep
TI  - Effects of arginine8-vasopressin administered at different times in the learning 
      of an appetitive visual discriminative task in mice.
PG  - 149-57
AB  - A visual discrimination task was used to investigate the effect of the 
      intra-hippocampal injection of arginine8-vasopressin (AVP) in male Balb/c mice at 
      different stages of the learning processes. The peptide was bilaterally 
      microinjected at a dose of 25 pg per animal, i.e. 833 pg/kg, into the ventral 
      hippocampus, in a volume of 0.3 microliter 10 min before either the first or the 
      second learning session, or immediately after the first or second learning 
      session. Following pre-session administration of AVP, no effect of the peptide 
      was observed on the session prior to which it was administered. On the other 
      hand, 48 h after the pre-first session treatment, it seems that AVP animals had 
      trouble learning the task. Following post-session injection of AVP, no effect was 
      observed when the treatment was given after the first learning session and a 
      tendency to improve performance was noted when the treatment was given after the 
      second learning session. Thus, whatever time AVP was injected during learning, 
      little or no effect was observed. These results and previous work on the same 
      behavioral task showing a clear enhancing effect of the peptide on retrieval 
      processes, suggest that prior experience or mnemonic context before AVP treatment 
      is as important a factor in understanding the effects of AVP on memory processes 
      as the administration route or the doses used.
FAU - Paban, V
AU  - Paban V
AD  - Laboratoire de Neurobiologie des Comportements, URA CNRS 372, Universite de 
      Provence IBHOP, Marseille, France.
FAU - Alescio-Lautier, B
AU  - Alescio-Lautier B
FAU - Devigne, C
AU  - Devigne C
FAU - Soumireu-Mourat, B
AU  - Soumireu-Mourat B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/*drug effects
MH  - Arginine Vasopressin/*pharmacology
MH  - Brain Mapping
MH  - Discrimination Learning/*drug effects
MH  - Hippocampus/*drug effects
MH  - Injections
MH  - Male
MH  - Mental Recall/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Motor Activity/drug effects
MH  - Retention, Psychology/drug effects
MH  - Visual Perception/*drug effects
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - S0166-4328(96)02275-9 [pii]
AID - 10.1016/s0166-4328(96)02275-9 [doi]
PST - ppublish
SO  - Behav Brain Res. 1997 Sep;87(2):149-57. doi: 10.1016/s0166-4328(96)02275-9.