PMID- 9331566
OWN - NLM
STAT- MEDLINE
DCOM- 19971125
LR  - 20061115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 20
IP  - 2
DP  - 1997 Oct
TI  - FISH identifies different types of duplications with 12q13-15 as the commonly 
      involved segment in B-cell lymphoproliferative malignancies characterized by 
      partial trisomy 12.
PG  - 155-66
AB  - Clinical, cytogenetic, fluorescence in situ hybridization (FISH), and Southern 
      blot data of 18 patients with different subtypes of B-cell non-Hodgkin's 
      lymphoma, cytogenetically characterized by partial trisomy 12, are presented. 
      These chromosomal changes occurred predominantly in clinically progressive 
      chronic lymphocytic leukemia, mixed cell type, and advanced-stage follicle center 
      cell lymphoma at the time of relapse or transformation into diffuse large cell 
      lymphoma. Partial trisomy 12 consistently included the long arm of chromosome 12, 
      either completely or partially, and resulted from dup(12q) or other 
      rearrangements involving chromosome 12. The duplications were cytogenetically 
      identified as dup(12)(q13q23), dup(12)(q13q22), or dup(12)(q13q15) in follicle 
      center cell lymphoma or t(14;18)-positive diffuse large cell lymphoma; 
      dup(12)(q13q22) or dup(12)(q13q24) in chronic lymphocytic leukemia; and 
      dup(12)(q13q21) in a case of t(14;18)-negative diffuse large cell lymphoma. FISH, 
      using library probes and a panel of YAC probes, mapped along the long arm of 
      chromosome 12, confirmed the cytogenetic results in all cases analyzed except for 
      three cases of t(14;18)-positive follicle center lymphoma or diffuse large cell 
      lymphoma with dup(12q). In these cases, FISH showed similar, possibly identical, 
      duplications, which involved a region more centromeric (12q11-21) than assumed by 
      karyotypic analysis (12q13-22 or 12q13-23) and included alphoid DNA sequences, a 
      combination hitherto unknown. In addition, commonly duplicated regions of 
      chromosome 12 could be defined: 12q11-21, including alphoid DNA sequences for 
      follicle center cell lymphoma or t(14;18)-positive diffuse large cell lymphoma, 
      12q13-22 for chronic lymphocytic leukemia, and 12p13-q15 for marginal zone cell 
      lymphoma, all of which overlapped in 12q13-15. Whether these regions, especially 
      12q13-15, may contain genes which are important in malignant transformation or 
      disease progression of B-cell lymphoproliferative malignancies characterized by 
      complete or partial trisomy 12 remains to be determined.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Center for Human Genetics, University of Leuven, Belgium.
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Michaux, L
AU  - Michaux L
FAU - Vermeesch, J R
AU  - Vermeesch JR
FAU - Meeus, P
AU  - Meeus P
FAU - Stul, M
AU  - Stul M
FAU - Criel, A
AU  - Criel A
FAU - Verhoef, G
AU  - Verhoef G
FAU - Thomas, J
AU  - Thomas J
FAU - Delannoy, A
AU  - Delannoy A
FAU - Louwagie, A
AU  - Louwagie A
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - Mecucci, C
AU  - Mecucci C
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Van den Berghe, H
AU  - Van den Berghe H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Blotting, Southern
MH  - Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multigene Family
MH  - Trisomy/*genetics
EDAT- 1997/10/23 22:24
MHDA- 2000/06/20 09:00
CRDT- 1997/10/23 22:24
PHST- 1997/10/23 22:24 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/10/23 22:24 [entrez]
AID - 10.1002/(SICI)1098-2264(199710)20:2<155::AID-GCC6>3.0.CO;2-2 [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Oct;20(2):155-66.