PMID- 9331947
OWN - NLM
STAT- MEDLINE
DCOM- 19980205
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 50
IP  - 3
DP  - 1997 Sep
TI  - Further diversification of the HLA-B locus in Central American Amerindians: new 
      B*39 and B*51 alleles in the Kuna of Panama.
PG  - 251-7
AB  - Several new HLA-B locus alleles have been discovered in South American 
      Amerindians. By contrast, analysis of the MHC class I alleles of North American 
      native populations has revealed few new HLA-B alleles. This suggests that the 
      HLA-B locus is evolving rapidly in South American populations. Here we describe 
      the HLA-B locus alleles present in individuals from a Central American tribe, the 
      Kuna of Panama. Using a sequence-based typing technique that separates alleles by 
      denaturing gradient gel electrophoresis (DGGE) followed by direct sequencing, we 
      determined the HLA-B alleles from eight Kunas. Two of the HLA-B alleles present 
      in the Kuna have been previously described in other South American Amerindian 
      populations; one allele has been characterized in a Mexican-American. We 
      characterized two new HLA-B alleles in the Kuna, HLA-B*3911 and HLA-B*5110. 
      HLA-B*3911 differed from HLA-B*3905 by only a single nucleotide substitution in 
      exon 3. This substitution resulted in an amino acid replacement of leucine by 
      arginine at residue 156 in the alpha 2 domain. Such a change may affect the 
      repertoire of peptides that are bound by this molecule. HLA-B*5110 differed 
      significantly from other HLA-B*51 alleles in that it is the result of an 
      unusually large intra-locus recombination event of minimally 216 nucleotides. 
      This recombination results in an allele that is part HLA-B*51 and part HLA-B*40. 
      Thus, more dramatic recombination events may also play a role in the rapid 
      evolution of the HLA-B locus in Amerindians.
FAU - Iwanaga, K K
AU  - Iwanaga KK
AD  - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, 
      USA.
FAU - Eberle, M
AU  - Eberle M
FAU - Kolman, C J
AU  - Kolman CJ
FAU - Bermingham, E
AU  - Bermingham E
FAU - Watkins, D I
AU  - Watkins DI
LA  - eng
SI  - GENBANK/AF004370
SI  - GENBANK/U74368
GR  - RR00167/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B39 Antigen)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - HLA-B Antigens/*genetics
MH  - HLA-B39 Antigen
MH  - HLA-B51 Antigen
MH  - Humans
MH  - Indians, Central American/*genetics
MH  - Molecular Sequence Data
MH  - Panama
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - 10.1111/j.1399-0039.1997.tb02868.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1997 Sep;50(3):251-7. doi: 10.1111/j.1399-0039.1997.tb02868.x.