PMID- 9332330
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20211203
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 98
IP  - 3
DP  - 1997 Sep
TI  - BCL6 gene rearrangements also occur in marginal zone B-cell lymphoma.
PG  - 719-25
AB  - Marginal zone B-cell lymphoma (MZBCL) represents a distinct subtype of B-cell 
      non-Hodgkin's lymphoma (NHL) which has been recently recognized and defined as a 
      disease entity. Cytogenetically, these lymphomas reveal a high prevalence of 
      trisomy 3, and recent data obtained by comparative genomic hybridization indicate 
      that the chromosomal regions 3q21-23 and 3q25-29 might be of particular 
      pathogenetic significance. We identified structural chromosomal abnormalities 
      involving the region 3q27 and rearrangements of the BCL6 proto-oncogene in three 
      out of 34 (9%) well-defined cases of extranodal, nodal and splenic MZBCL using 
      cytogenetic analysis. Southern blot, and fluorescence in situ hybridization 
      (FISH). All three cases were characterized by a t(3;14)(q27;q32). Two of them 
      showed additional chromosomal abnormalities including trisomy 3, which was found 
      in one case. The patients displayed extranodal disease and did not demonstrate 
      any striking clinical and histological differences when compared with MZBCL 
      lacking BCL6 rearrangement. The present study for the first time demonstrates the 
      occurrence of t(3;14)/BCL6 gene rearrangement in MZBCL, thus suggesting a role of 
      the BCL6 proto-oncogene in the pathogenesis of MZBCL.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Centre for Human Genetics, University of Leuven, Belgium.
FAU - Pittaluga, S
AU  - Pittaluga S
FAU - Stul, M
AU  - Stul M
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Michaux, L
AU  - Michaux L
FAU - Thomas, J
AU  - Thomas J
FAU - Verhoef, G
AU  - Verhoef G
FAU - Verhest, A
AU  - Verhest A
FAU - Depardieu, C
AU  - Depardieu C
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
FAU - Van den Berghe, H
AU  - Van den Berghe H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aged
MH  - Blotting, Southern
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Transcription Factors/*genetics
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - 10.1046/j.1365-2141.1997.2703087.x [doi]
PST - ppublish
SO  - Br J Haematol. 1997 Sep;98(3):719-25. doi: 10.1046/j.1365-2141.1997.2703087.x.