PMID- 9332365
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 197
IP  - 1-2
DP  - 1997 Sep 15
TI  - The human PD-1 gene: complete cDNA, genomic organization, and developmentally 
      regulated expression in B cell progenitors.
PG  - 177-87
AB  - We report the complete cDNA sequence and the genomic structure of the human PD-1 
      homologue. An analysis of the expression pattern of the human PD-1 gene (hPD-1) 
      and the murine PD-1 gene (mPD-1) in developing bone marrow B-lineage cells was 
      also undertaken. The full length hPD-1 cDNA is 2106 nucleotides long and encodes 
      a predicted protein of 288 amino acid residues. The hPD-1 and mPD-1 genes share 
      70% homology at the nucleotide level and 60% homology at the amino acid level. 
      Four potential sites for N-linked glycosylation are conserved, as are a stretch 
      of amino acids between two cysteine residues resembling a V-set immunoglobulin 
      domain, and another region containing a motif similar to an immunoreceptor 
      tyrosine-based inhibitory motif. Isolation of the genomic locus of the hPD-1 gene 
      reveals that the gene is composed of five exons located on human chromosome 2 at 
      band q37. The 5' flanking region lacks TATA and CAAT cis-acting elements, but 
      includes a number of potential transcription factor binding sites and a dominant 
      transcription start site. The mPD-1 gene was preferentially expressed in pro-B 
      cells from murine adult bone marrow. Although hPD-1 was not preferentially 
      expressed in pro-B cells from human fetal bone marrow, treatment of isolated 
      pro-B cells with interleukin-7 resulted in a dramatic increase in expression. 
      These data suggest that PD-1 may play a role in B-cell differentiation during the 
      pro-B cell stage.
FAU - Finger, L R
AU  - Finger LR
AD  - Department of Medicine, New York Medical College, Elmsford 10523, USA.
FAU - Pu, J
AU  - Pu J
FAU - Wasserman, R
AU  - Wasserman R
FAU - Vibhakar, R
AU  - Vibhakar R
FAU - Louie, E
AU  - Louie E
FAU - Hardy, R R
AU  - Hardy RR
FAU - Burrows, P D
AU  - Burrows PD
FAU - Billips, L G
AU  - Billips LG
LA  - eng
SI  - GENBANK/U64863
SI  - GENBANK/U64864
GR  - AI-26782/AI/NIAID NIH HHS/United States
GR  - AI-34568/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Surface)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-7)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Pdcd1 protein, mouse)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
EIN - Gene 1997 Dec 12;203(2):253
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens, CD
MH  - *Antigens, Surface
MH  - Apoptosis Regulatory Proteins
MH  - B-Lymphocytes/*physiology
MH  - Base Sequence
MH  - Bone Marrow/immunology
MH  - Cells, Cultured
MH  - Chromosomes, Human, Pair 2/genetics
MH  - DNA, Complementary/*genetics
MH  - Female
MH  - Gene Expression Regulation, Developmental/*genetics/immunology
MH  - Genes/genetics
MH  - Hematopoietic Stem Cells/*physiology
MH  - Humans
MH  - Interleukin-7/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Programmed Cell Death 1 Receptor
MH  - Proteins/*genetics
MH  - RNA, Messenger/analysis
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Restriction Mapping
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - S0378-1119(97)00260-6 [pii]
AID - 10.1016/s0378-1119(97)00260-6 [doi]
PST - ppublish
SO  - Gene. 1997 Sep 15;197(1-2):177-87. doi: 10.1016/s0378-1119(97)00260-6.