PMID- 9334169
OWN - NLM
STAT- MEDLINE
DCOM- 19971117
LR  - 20231213
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 272
IP  - 42
DP  - 1997 Oct 17
TI  - Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF 
      receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase 
      requirement for activation of activating protein 1 and NFkappaB but not of c-Jun 
      N-terminal kinase/stress-activated protein kinase.
PG  - 26079-82
AB  - Like other members of the tumor necrosis factor (TNF) receptor family, p55 TNF 
      receptor 1 (TNF-R1) lacks intrinsic signaling capacity and transduces signals by 
      recruiting associating molecules. The TNF-R1 associated death domain protein 
      interacts with the p55 TNF-R1 cytoplasmic domain and recruits the Fas-associated 
      death domain protein (which directly activates the apoptotic proteases), the 
      protein kinase receptor interacting protein, and TNF receptor-associated factor 2 
      (TRAF2). TRAF2 has previously been demonstrated to activate both transcription 
      factor nuclear factor kappaB (NFkappaB) and the c-Jun N-terminal 
      kinase/stress-activated protein kinase (JNK/SAPK) pathway, which in turn 
      stimulates transcription factor activating protein 1 (AP1) mainly via 
      phosphorylation of the c-Jun component. We have investigated the signaling 
      properties of NFkappaB-inducing kinase (NIK), a TRAF2-associated protein kinase 
      that mediates NFkappaB induction. NIK was found to be unable to activate 
      JNK/SAPK, mitogen-activated protein kinase, or p38 kinase. Moreover, NIK was not 
      required for JNK/SAPK activation by TNF-R1, thus representing the first TNF-R1 
      complex component to dissect the NFkappaB and the JNK/SAPK pathways. Despite 
      being unable to activate JNK/SAPK and mitogen-activated protein kinase, NIK 
      strongly activated AP1 and was required for TNF-R1-induced AP1 activation. 
      Therefore, NIK links TNF-R1 to a novel, JNK/SAPK-independent, AP1 activation 
      pathway.
FAU - Natoli, G
AU  - Natoli G
AD  - Fondazione Andrea Cesalpino and Istituto I Clinica Medica, Policlinico Umberto I, 
      Universita degli Studi di Roma La Sapienza, Viale del Policlinico 155, 00161 
      Rome, 86100 Italy.
FAU - Costanzo, A
AU  - Costanzo A
FAU - Moretti, F
AU  - Moretti F
FAU - Fulco, M
AU  - Fulco M
FAU - Balsano, C
AU  - Balsano C
FAU - Levrero, M
AU  - Levrero M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Cell Line
MH  - Enzyme Activation
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases
MH  - *Mitogen-Activated Protein Kinases
MH  - NF-kappa B/*metabolism
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*metabolism
MH  - Recombinant Proteins/metabolism
MH  - *Signal Transduction
MH  - TNF Receptor-Associated Factor 2
MH  - NF-kappaB-Inducing Kinase
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - S0021-9258(18)66386-0 [pii]
AID - 10.1074/jbc.272.42.26079 [doi]
PST - ppublish
SO  - J Biol Chem. 1997 Oct 17;272(42):26079-82. doi: 10.1074/jbc.272.42.26079.