PMID- 9334290
OWN - NLM
STAT- MEDLINE
DCOM- 20060324
LR  - 20190831
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 2
DP  - 1997 Nov 1
TI  - Role of MMTV integration locus cellular genes in breast cancer.
PG  - d519-26
AB  - Mouse mammary tumorigenesis as a result of mouse mammary tumor virus (MMTV) 
      integrations has helped to identify a wide variety of interesting genes that play 
      a role in mammary development and tumorigenesis. Several such genes int1/wnt1, 
      wnt3, wnt 10B, int2/fgf3, fgf4, int3/notch and int6 have been shown to be 
      genetically altered in naturally formed mammary tumors as a consequence of MMTV 
      integration. Some of these genes have been well characterised and examined in in 
      vivo breast cancer transgenic models for their potential for tumorigenesis. 
      Overexpression of one or more of these genes have resulted in a striking 
      proliferation of mammary gland epithelium of both female and male transgenic 
      mice. Our own studies have demonstrated overexpression of int5/aromatase in 
      mammary glands of virgin and postlactational females leads to the induction of 
      various preneoplastic and neoplastic changes that are similar to early breast 
      cancer, that may, in turn, increase the risks for developing breast cancer. 
      Therefore, further understanding of these genes should provide new insights to 
      their involvement and mechanism of action in breast cancer.
FAU - Tekmal, R R
AU  - Tekmal RR
AD  - Department of Gynecology and Obstetrics and Winship Cancer Center, Emory 
      University School of Medicine, Atlanta, GA 30322-4710, USA. rtekmal@emory.edu
FAU - Keshava, N
AU  - Keshava N
LA  - eng
GR  - CA57559/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 19971101
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Carcinogens)
RN  - 0 (Eukaryotic Initiation Factor-3)
RN  - 0 (FGF3 protein, human)
RN  - 0 (Fibroblast Growth Factor 3)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Wild
MH  - Breast Neoplasms/*genetics/physiopathology
MH  - Carcinogens
MH  - Cell Transformation, Neoplastic
MH  - Disease Models, Animal
MH  - Eukaryotic Initiation Factor-3/physiology
MH  - Female
MH  - Fibroblast Growth Factor 3/physiology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Mammary Neoplasms, Animal/*genetics/virology
MH  - Mammary Tumor Virus, Mouse/pathogenicity
MH  - Mice
MH  - Mice, Transgenic
MH  - Wnt Proteins/*physiology
RF  - 58
EDAT- 1997/10/23 00:00
MHDA- 2006/03/25 09:00
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 2006/03/25 09:00 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - 10.2741/a209 [doi]
PST - epublish
SO  - Front Biosci. 1997 Nov 1;2:d519-26. doi: 10.2741/a209.