PMID- 9334920
OWN - NLM
STAT- MEDLINE
DCOM- 19971113
LR  - 20131121
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 53
IP  - 2
DP  - 1997 Oct
TI  - Infection of a human retinal pigment epithelial cell line with human herpesvirus 
      6 variant A.
PG  - 105-10
AB  - A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its 
      susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 
      cells to HHV-6A induced the formation of multinucleated giant cells, which was 
      suppressed by an inhibitor of viral DNA synthesis. In the giant cells, 
      herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral 
      glycoprotein B was detected by immunofluorescence assay. These results indicate 
      that K-1034 cells are susceptible to HHV-6A and suggest that HHV-6A has an 
      ability to directly destroy epithelial cells.
FAU - Arao, Y
AU  - Arao Y
AD  - Department of Pathology, National Institute of Health, Tokyo, Japan.
FAU - Soushi, S
AU  - Soushi S
FAU - Sato, Y
AU  - Sato Y
FAU - Moriishi, E
AU  - Moriishi E
FAU - Ando, Y
AU  - Ando Y
FAU - Yamada, M
AU  - Yamada M
FAU - Padilla, J
AU  - Padilla J
FAU - Uno, F
AU  - Uno F
FAU - Nii, S
AU  - Nii S
FAU - Kurata, T
AU  - Kurata T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
RN  - 0 (Nucleic Acid Synthesis Inhibitors)
RN  - 0 (Viral Envelope Proteins)
RN  - 148770-71-2 (glycoprotein B, human herpesvirus-6)
RN  - N919E46723 (Phosphonoacetic Acid)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Cytopathogenic Effect, Viral
MH  - DNA, Viral/biosynthesis
MH  - Epithelial Cells/*virology
MH  - Ganciclovir/pharmacology
MH  - Giant Cells
MH  - Herpesvirus 6, Human/*pathogenicity/physiology
MH  - Humans
MH  - Nucleic Acid Synthesis Inhibitors/pharmacology
MH  - Phosphonoacetic Acid/pharmacology
MH  - Pigment Epithelium of Eye/*virology
MH  - Viral Envelope Proteins/analysis
EDAT- 1997/10/23 22:31
MHDA- 2000/06/20 09:00
CRDT- 1997/10/23 22:31
PHST- 1997/10/23 22:31 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/10/23 22:31 [entrez]
AID - 10.1002/(SICI)1096-9071(199710)53:2<105::AID-JMV1>3.0.CO;2-D [pii]
PST - ppublish
SO  - J Med Virol. 1997 Oct;53(2):105-10.