PMID- 9334988
OWN - NLM
STAT- MEDLINE
DCOM- 19971126
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 66
IP  - 1-2
DP  - 1997 Sep 10
TI  - Oxytocin decreases blood pressure in male but not in female spontaneously 
      hypertensive rats.
PG  - 15-8
AB  - The aim of the present study was to investigate the effects of repeated 
      injections of oxytocin on blood pressure and heart rate in spontaneously 
      hypertensive rats (SHR). For this purpose subcutaneous (s.c.) injections of 
      oxytocin 1 mg/kg or saline were given for 5 days to male and female SHR. Blood 
      pressure and heart rate were measured daily before, during and after the oxytocin 
      treatment period. In male rats, a significant decrease in blood pressure 
      (systolic; p < 0.01, diastolic; p < 0.05), but no effect on heart rate, was seen 
      the day after the first injection of oxytocin, when compared to saline-treated 
      controls. Blood pressure decreased further in response to each injection and a 
      maximal difference of 21 mmHg (systolic) (p < 0.01), compared to controls, was 
      reached after the last injection. The significant effect was gone 3 days after 
      the last injection, although a tendency to a lower blood pressure in the 
      oxytocin-treated rats persisted. On day 10, the oxytocin-treated SHR males again 
      had a significantly lower systolic blood pressure (p < 0.05). In female SHR, the 
      same treatment with oxytocin affected neither blood pressure nor heart rate. 
      These results show that oxytocin may cause a sustained decrease in blood 
      pressure, without affecting heart rate, in male but not in female SHR.
FAU - Petersson, M
AU  - Petersson M
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden. 
      maria.petersson@fyfa.ki.se
FAU - Lundeberg, T
AU  - Lundeberg T
FAU - Uvnas-Moberg, K
AU  - Uvnas-Moberg K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Hypertension/*physiopathology
MH  - Injections, Subcutaneous
MH  - Male
MH  - Oxytocin/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - S0165-1838(97)00040-4 [pii]
AID - 10.1016/s0165-1838(97)00040-4 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1997 Sep 10;66(1-2):15-8. doi: 10.1016/s0165-1838(97)00040-4.