PMID- 9339247
OWN - NLM
STAT- MEDLINE
DCOM- 19971204
LR  - 20151119
IS  - 0327-6309 (Print)
IS  - 0327-6309 (Linking)
VI  - 47
IP  - 3
DP  - 1997
TI  - Multireceptor interactions of haloperidol on rat cerebral frontal cortex "in 
      vitro".
PG  - 173-8
AB  - As several side effects of neuroleptics would be related to their interactions 
      with several neurotransmitter receptors (R) haloperidol action on muscarinic 
      cholinergic (mACh) R on frontal cerebral cortex preparations was analyzed. Here 
      we show that haloperidol was able to inhibit in a concentration dependent manner 
      the binding of specific mAChR radiolabeled antagonist on cerebral cortex 
      membranes. This effect would be related to its interaction on mAChR of the M1 
      subtype as haloperidol blocked the stimulation of phosphoinositides (PIs) 
      turnover induced by low concentrations of carbachol similarly as the M1 
      antagonist pirenzepine. However at high carbachol concentrations haloperidol 
      triggered a potentiating stimulation of PIs hydrolysis that was only blocked by 
      the alpha 1 adrenergic antagonist prazosin indicating an alpha 1 agonistic action 
      of haloperidol on these Rs. These multireceptor actions of haloperidol found "in 
      vitro" would strengthen its association with "in vivo" neuroleptic-induced side 
      effects.
FAU - Borda, T G
AU  - Borda TG
AD  - CEFYBO-CONICET, Buenos Aires, Argentina.
FAU - Cremaschi, G
AU  - Cremaschi G
LA  - eng
PT  - Journal Article
PL  - Argentina
TA  - Acta Physiol Pharmacol Ther Latinoam
JT  - Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la 
      Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion 
      Latinoamericana de Farmacologia
JID - 9200300
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Inositol Phosphates)
RN  - 0 (Muscarinic Agonists)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Receptors, Muscarinic)
RN  - 6581-06-2 (Quinuclidinyl Benzilate)
RN  - 8Y164V895Y (Carbachol)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Binding Sites
MH  - Carbachol
MH  - Cerebral Cortex/*drug effects
MH  - Haloperidol/*pharmacology
MH  - In Vitro Techniques
MH  - Inositol Phosphates
MH  - Muscarinic Agonists
MH  - *Muscarinic Antagonists
MH  - Quinuclidinyl Benzilate
MH  - Rats
MH  - Receptors, Muscarinic/*drug effects
EDAT- 1997/01/01 00:00
MHDA- 1997/10/27 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/10/27 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Physiol Pharmacol Ther Latinoam. 1997;47(3):173-8.