PMID- 9341881
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20211203
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 100
IP  - 5-6
DP  - 1997 Oct
TI  - The germinal center kinase gene and a novel CDC25-like gene are located in the 
      vicinity of the PYGM gene on 11q13.
PG  - 611-9
AB  - Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type 
      glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome 
      contains additional disease-related loci implicated in the development of 
      insulin-dependent diabetes mellitus, familial paraganglioma type 2, 
      spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) 
      described in B-cell non-Hodgkin's lymphoma. We approached cloning of candidate 
      disease genes from 11q13 by large-scale genomic sequencing. We obtained > 106 kb 
      of sequence around the PYGM gene and established a transcriptional map that 
      includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger 
      protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte 
      serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) 
      gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a 
      novel ubiquitously expressed gene of unknown function (germinal center kinase- 
      neighboring gene, GCKNG).
FAU - Kedra, D
AU  - Kedra D
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - Seroussi, E
AU  - Seroussi E
FAU - Fransson, I
AU  - Fransson I
FAU - Trifunovic, J
AU  - Trifunovic J
FAU - Clark, M
AU  - Clark M
FAU - Lagercrantz, J
AU  - Lagercrantz J
FAU - Blennow, E
AU  - Blennow E
FAU - Mehlin, H
AU  - Mehlin H
FAU - Dumanski, J
AU  - Dumanski J
LA  - eng
SI  - GENBANK/Y12334
SI  - GENBANK/Y12335
SI  - GENBANK/Y12336
SI  - GENBANK/Y12337
SI  - GENBANK/Y12338
SI  - GENBANK/Y12339
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DMPK protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Germinal Center Kinases)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA Splicing Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (SF1 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (ras-GRF1)
RN  - EC 2.4.1.- (Phosphorylases)
RN  - EC 2.7.1.- (CDC42BPA protein, human)
RN  - EC 2.7.11.1 (Myotonin-Protein Kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Carrier Proteins/genetics
MH  - Cell Cycle Proteins/*genetics
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Cloning, Molecular/methods
MH  - *DNA-Binding Proteins
MH  - Exons/genetics
MH  - Genes/genetics
MH  - Germinal Center Kinases
MH  - Humans
MH  - Introns/genetics
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Muscles/enzymology
MH  - Myotonic Dystrophy
MH  - Myotonin-Protein Kinase
MH  - Nuclear Proteins/genetics
MH  - Phosphoprotein Phosphatases/*genetics
MH  - Phosphorylases/*genetics
MH  - Protein Serine-Threonine Kinases/*genetics
MH  - RNA Splicing Factors
MH  - RNA, Messenger/analysis
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - *Transcription Factors
MH  - ras-GRF1
EDAT- 1997/10/28 00:00
MHDA- 1997/10/28 00:01
CRDT- 1997/10/28 00:00
PHST- 1997/10/28 00:00 [pubmed]
PHST- 1997/10/28 00:01 [medline]
PHST- 1997/10/28 00:00 [entrez]
AID - 10.1007/s004390050562 [doi]
PST - ppublish
SO  - Hum Genet. 1997 Oct;100(5-6):611-9. doi: 10.1007/s004390050562.