PMID- 9341884
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 100
IP  - 5-6
DP  - 1997 Oct
TI  - Frequent gains on chromosome arms 1q and/or 8q in human endometrial cancer.
PG  - 629-36
AB  - Comparative genomic hybridization (CGH) was employed to survey genomic regions 
      with increased and decreased copy number of the DNA sequence in 15 endometrial 
      cancers [10 cases with microsatellite instability positive (MI+) and 5 cases with 
      MI-]. Twelve of these 15 tumors (80%) showed abnormalities in copy number at one 
      or more of the chromosomal regions. There were no regions with frequent 
      chromosomal losses. Conversely, 11 of 15 cases (73%) showed gains on chromosome 
      arms 1q (8/15; 53%) and/or 8q (6/15; 40%). Concordant gains of both chromosome 
      arms 1q and 8q were observed in all three endometrial cancers of histological 
      grade 3. These results suggest that these two chromosomal regions may contain 
      genes whose increased expression contributes to development and/or progression of 
      endometrial carcinogenesis. Two cases were further analyzed by fluorescence in 
      situ hybridization (FISH) using three probes on chromosome 1 and two probes on 
      chromosome 8 to more accurately determine increases in copy number. We found 
      gains of chromosome 1q to 2.9-3.6 copies per cell and on 8q to 4.4 copies per 
      cell.
FAU - Suzuki, A
AU  - Suzuki A
AD  - Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, 
      Japan.
FAU - Fukushige, S
AU  - Fukushige S
FAU - Nagase, S
AU  - Nagase S
FAU - Ohuchi, N
AU  - Ohuchi N
FAU - Satomi, S
AU  - Satomi S
FAU - Horii, A
AU  - Horii A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Chromosome Aberrations/*genetics
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Endometrial Neoplasms/*genetics/pathology
MH  - Female
MH  - Gene Dosage
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - In Situ Hybridization, Fluorescence/methods
EDAT- 1997/10/28 00:00
MHDA- 1997/10/28 00:01
CRDT- 1997/10/28 00:00
PHST- 1997/10/28 00:00 [pubmed]
PHST- 1997/10/28 00:01 [medline]
PHST- 1997/10/28 00:00 [entrez]
AID - 10.1007/s004390050565 [doi]
PST - ppublish
SO  - Hum Genet. 1997 Oct;100(5-6):629-36. doi: 10.1007/s004390050565.